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Phospholipase A2 inhibition
Assignee: Pharmacia and Upjohn Co
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Filing: 1979-10-11
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Granted: 1980-12-16
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Expires: 1999-10-11
Abstract
Abstract Phospholipase A 2 inhibition the present invention relates to a method for treating or preventing a phospholipase A 2 mediated condition (PMC) in a mammal suffering from or susceptible to such a condition. The method involves administering to such a mammal an amount effective to treat the condition of a compound selected from a certain group of butyrophenones.
Inventors
- 👤 Donald P. Wallach
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-26 09:41
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/13; A61K31/135
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
95 words
A method for treating a phospholipase A 2 mediated condition (PMC) in a mammal suffering from the development of said PMC which comprises administering to said mammal an amount of a compound of formula I: wherein R 1 is R 1 --N(R 3 )--CH 2 --CH 2 --CH 2 --R 2 ##STR16## R 2 is ##STR17## R 3 is H or CH 3 , with the proviso that R 3 is -CH 3 only when R 1 is ##STR18## or a pharmacologically acceptable acid addition salt or salt hydrate thereof, effective to treat said PMC.
Claim 2
Independent Claim
95 words
A method for treating a phospholipase A 2 mediated condition (PMC) in a mammal suffering from the development of said PMC which comprises administering to said mammal an amount of a compound of formula I: wherein R 1 is R 1 --N(R 3 )--CH 2 --CH 2 --CH 2 --R 2 ##STR16## R 2 is ##STR17## R 3 is H or CH 3 , with the proviso that R 3 is -CH 3 only when R 1 is ##STR18## or a pharmacologically acceptable acid addition salt or salt hydrate thereof, effective to treat said PMC.
References Cited (Backward Citations)
US3979444A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-16 | 1984-06-16 | 1984-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-16 | 1988-06-16 | 1988-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-16 | 1992-06-16 | 1992-12-16 | $7700.00 | Window Closed / Lapsed |