US4239649A
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Cholesterol standard
Assignee: Covidien AG
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Filing: 1979-01-25
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Granted: 1980-12-16
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Expires: 1999-01-25
Abstract
Abstract A cholesterol standard solution containing a predetermined amount of cholesterol, alcohol, and a long chain alkyl substituted betaine.
Inventors
- 👤 E. Melvin Gindler
- 👤 Louis M. Mezei
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 10:25
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; G01N33/92; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/104165
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
77 words
A standard solution useful in the quantitative determination of cholesterol consisting essentially of a predetermined amount of cholesterol, a water miscible alcohol present in an amount sufficient to dissolve said cholesterol to thereby form a solution, and a long chain alkyl substituted betaine solution in both water and alcohol and present in an amount such that said solution, as prepared, has extended mechanical stability and can be fashioned into an aqueous calibrator solution without precipitation of cholesterol.
Claim 2
Dependent Claim
77 words
A standard solution useful in the quantitative determination of cholesterol consisting essentially of a predetermined amount of cholesterol, a water miscible alcohol present in an amount sufficient to dissolve said cholesterol to thereby form a solution, and a long chain alkyl substituted betaine solution in both water and alcohol and present in an amount such that said solution, as prepared, has extended mechanical stability and can be fashioned into an aqueous calibrator solution without precipitation of cholesterol.
Claim 3
Dependent Claim
14 words
The standard solution of claim 1 containing water in addition to the identified ingredients.
Claim 4
Dependent Claim
11 words
The standard solution of claim 1 wherein the alcohol is n-propanol.
Claim 5
Dependent Claim
11 words
The standard solution of claim 2 wherein the alcohol is n-propanol.
Claim 6
Dependent Claim
29 words
The standard solution of claim 1, 2, 3 or 4 wherein the betaine has the structure. ##STR2## wherein R is an alkyl group containing 8 to 18 carbon atoms.
Claim 7
Dependent Claim
14 words
The standard solution of claim 5 wherein R contains 12 to 16 carbon atoms.
Claim 8
Dependent Claim
41 words
The standard solution of claim 1 wherein the respective concentrations of said cholesterol, said alcohol and said betaine in said solution is as follows: Cholesterol: less than about 800 mg/dl Alcohol: at least about 50% (V/V) Betaine: between about 2-20 g/dl
Claim 9
Dependent Claim
15 words
The solution of claim 7 wherein said betaine concentration is less than about 10 g/dl.
Claim 10
Dependent Claim
56 words
A standard solution useful in the quantitative determination of cholesterol consisting essentially of water, a predetermined amount of cholesterol, at least about 50% by volume of said solution of n-propanol, and between about 2 and 20 g/dl of a betaine having the structure ##STR3## wherein R is an alkyl group containing 8 to 18 carbon atoms.
Claim 11
Dependent Claim
56 words
A standard solution useful in the quantitative determination of cholesterol consisting essentially of water, a predetermined amount of cholesterol, at least about 50% by volume of said solution of n-propanol, and between about 2 and 20 g/dl of a betaine having the structure ##STR3## wherein R is an alkyl group containing 8 to 18 carbon atoms.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-16 | 1984-06-16 | 1984-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-16 | 1988-06-16 | 1988-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-16 | 1992-06-16 | 1992-12-16 | $7700.00 | Window Closed / Lapsed |