2-Decarboxy-2-aminomethyl-6a-carba-PGI2 compounds

Claim 1

A compound of the formula ##STR117## wherein W 2 is α-OH:β-H, α-H:β-OH, oxo, or α-H:β-H; wherein D is (1) --(CH 2 ) d --, wherein d is one to 5, inclusive, (2) --(CH 2 ) d --CF 2 --, wherein d is one to 5, inclusive, (3) --(CH 2 ) k --CH═CH--, wherein k is one or 2; wherein one of R 4 and R 5 is hydrogen, and the other is hydrogen, alkyl of one to 12 carbon atoms, inclusive, benzyl, or phenyl; wherein R 11 is --C(R.sub.12)(R.sub.13)--C.sub.g H.sub.2g --CH.sub.3, (1) wherein C g H 2g is alkylene of one to 9 carbon atoms, inclusive, with one to 5 carbon atoms, inclusive, in the chain between --CR 12 R 13 -- and terminal methyl, wherein R 12 and R 13 are hydrogen, alkyl of one to 4 carbon atoms, inclusive, or fluoro, being the same or different, with the proviso that one of R 12 and R 13 is fluoro only when the other is hydrogen or fluoro; --C(R.sub.12)(R.sub.13)--Z--(Ph), (2) wherein R 12 and R 13 are as defined above; wherein Z represents an oxa atom (--O--) or C j H 2j , wherein C j H 2j is a valence bond or alkylene of one to 9 carbon atoms, inclusive, substituted with zero, one, or 2 fluoro, with one to 6 carbon atoms, inclusive between --CR 12 R 13 -- and (Ph), wherein (Ph) is phenyl or phenyl substituted by (T)s, wherein T is alkyl of one to 4 carbon atoms, inclusive, fluoro, chloro, trifluoromethyl, or --OR 14 , wherein R 14 is alkyl of one to 4 carbon atoms, inclusive, and s is zero, one, 2, or 3, with the proviso that not more than two T s are other than alkyl and when s is 2 or 3 the T s are either the same or different; or cis--CH.sub.2 --CH═CH CH.sub.2 CH.sub.3 ; (3) ps wherein Q 1 is α-OH:β-R 8 or α-R 8 :β-OH, wherein R 8 is hydrogen or methyl; wherein X is trans--CH═CH--, cis-CH═CH--, --C.tbd.C--, or --CH 2 CH 2 --.