US3935240A
Expired / Lapsed
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Cyclopentylheptenoic acids and derivatives
Assignee: Imperial Chemical Industries Ltd
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Filing: 1973-10-26
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Granted: 1976-01-27
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Expires: 1993-10-26
Abstract
Abstract The disclosure relates to novel intermediates, for use in the manufacture of known prostaglandins and prostaglandin-like compounds, for example aldehydes such as methyl 7-[2 beta -formyl-3 alpha -hydroxy-5 alpha -(4-phenylbenzoyloxy)cyclopent-1 alpha -yl]hetp-5-cis-enoate and enones such as methyl 15-oxo-9 alpha ,11 alpha -di(4-phenylbenzoyloxy)-5-cis,13-trans-prostadienoate, processes for their manufacture, and their conversion to prostaglandins or prostaglandin-like compounds.
Inventors
- 👤 Keith Blakeney Mallion
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 01:39
CPC Classifications
C; C07; C07D; C07D307/00; C07D307/77; C07D307/93; C07D307/935; C07C; C07C405/00; C07D309/00; C07D309/02; C07D309/08; C07D309/10; C07D309/12; C07D313/00
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
66 words
An aldehyde of the formula: ##SPC7## wherein R 1 is carboxy or alkoxycarbonyl of up to 11 carbon atoms, A is cis-vinylene, R 2 and R 3 , which may be the same or different, are hydroxy, 3,5-dinitrobenzoyloxy or hydrocarbon aroyloxy of up to 15 carbon atoms and bearing 0 or 1 alkyl of 1 to 4 carbon atoms on carbon atom 2, 3 or 4.
Claim 2
Dependent Claim
66 words
An aldehyde of the formula: ##SPC7## wherein R 1 is carboxy or alkoxycarbonyl of up to 11 carbon atoms, A is cis-vinylene, R 2 and R 3 , which may be the same or different, are hydroxy, 3,5-dinitrobenzoyloxy or hydrocarbon aroyloxy of up to 15 carbon atoms and bearing 0 or 1 alkyl of 1 to 4 carbon atoms on carbon atom 2, 3 or 4.
Claim 3
Dependent Claim
53 words
The aldehyde of claim 1 wherein R 1 is carboxy, methoxycarbonyl, n-butoxycarbonyl or n-decyloxycarbonyl, A is cis-vinylene, R 2 and R 3 , which may be the same or different, are hydroxy, benzoyloxy, 4-phenylbenzoyloxy or 3,5-dinitrobenzoyloxy and the alkyl substituent which may be present on carbon atom 2, 3 or 4 is methyl.
Claim 4
Dependent Claim
16 words
The aldehyde of claim 1 which is selected from methyl 7-[2β-formyl-3α,5α-di(4-phenylbenzoyloxy)cyclopent-1.alpha.-yl]hept-5-cis-enoate, methyl 7-[2β-formyl-3α,5α-dihydroxycyclopent-1α-yl]hept-5-cis-enoate and methyl 7-[2β-formyl-3α-hydroxy-5α-(4-phenylbenzoyloxy)cyclopent-1α-yl]hept-5-cis-enoate.
Claim 5
Dependent Claim
32 words
An aldehyde according to claim 1 wherein R 2 is hydrocarbon aroyloxy of up to 15 carbon atoms and R 3 is hydroxy or hydrocarbon aroyloxy of up to 15 carbon atoms.
Claim 6
Dependent Claim
23 words
An aldehyde according to claim 1 wherein R 2 is hydrocarbon aroyloxy of up to 15 carbon atoms and R 3 is hydroxy.
Claim 7
Dependent Claim
9 words
The aldehyde of claim 1 which is methyl 7-[2β-formyl-3α-hydroxy-5α-(4-phenylbenzoyloxy)-cyclopent-1α-yl]hept-5-cis-enoate.
References Cited (Backward Citations)
US3887587A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-26 | 1979-07-28 | 1980-01-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-26 | 1983-07-28 | 1984-01-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-26 | 1987-07-28 | 1988-01-27 | $7700.00 | Window Closed / Lapsed |