Patent US4237140A successfully refreshed from Google Patents.
US4237140A
Expired / Lapsed
US
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Analgesic mixture of nalbuphine and acetaminophen
Assignee: Bristol Myers Squibb Pharma Co
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Filing: 1979-05-18
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Granted: 1980-12-02
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Expires: 1999-05-18
Abstract
Abstract A composition consisting essentially of nalbuphine and acetaminophen gives unexpectedly enhanced analgesic activity.
Inventors
- 👤 John R. Dudzinski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 19:19
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/435; A61K31/47; A61K31/485; A61P; A61P25/00; A61P25/04
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
34 words
A pharmaceutical composition consisting essentially of (a) nalbuphine or a pharmaceutically suitable acid addition salt thereof and (b) acetaminophen in a weight ratio of (a) to (b) of from about 1:2 to about 1:70.
Claim 2
Dependent Claim
34 words
A pharmaceutical composition consisting essentially of (a) nalbuphine or a pharmaceutically suitable acid addition salt thereof and (b) acetaminophen in a weight ratio of (a) to (b) of from about 1:2 to about 1:70.
Claim 3
Dependent Claim
16 words
The composition of claim 1 wherein the weight ratio is from about 1:8 to about 1:60.
Claim 4
Dependent Claim
16 words
The composition of claim 1 wherein the weight ratio is from about 1:15 to about 1:50.
Claim 5
Dependent Claim
14 words
The composition of claim 1 wherein the nalbuphine is present as the hydrochloride salt.
Claim 6
Dependent Claim
13 words
The composition of claim 1 which contains in addition a suitable pharmaceutical carrier.
Claim 7
Dependent Claim
13 words
The composition of claim 2 which contains in addition a suitable pharmaceutical carrier.
Claim 8
Dependent Claim
13 words
The composition of claim 3 which contains in addition a suitable pharmaceutical carrier.
Claim 9
Dependent Claim
13 words
The composition of claim 4 which contains in addition a suitable pharmaceutical carrier.
Claim 10
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the compoisition of claim 1.
Claim 11
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 2.
Claim 12
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 3.
Claim 13
Dependent Claim
24 words
A method of alleviating pain in a mammal which comprises administering to the mammal an effective analgesic amount of the composition of claim 4.
References Cited (Backward Citations)
US3393197A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-02 | 1984-06-02 | 1984-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-02 | 1988-06-02 | 1988-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-02 | 1992-06-02 | 1992-12-02 | $7700.00 | Window Closed / Lapsed |