US4237128A
Expired / Lapsed
US
⏱️ 0.0 years remaining
7-[2-(2-Amino-4-thiazolyl)-2-[(1-carboxy-1,1-dialkyl)alkoxyimino]acetamido]cephem sulfoxides
Assignee: ER Squibb and Sons LLC
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Filing: 1979-04-12
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Granted: 1980-12-02
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Expires: 1999-04-12
Abstract
Abstract Compounds of the formula <IMAGE> wherein R is hydrogen, sodium, potassium, or certain ester groups; R1 is in the alpha -configuration and is hydrogen or methoxy; R2 and R3 are independently selected from methyl, ethyl, i-propyl, and n-propyl; R4 is hydrogen, sodium, potassium or certain ester groups, and X is hydrogen, <IMAGE> +TR <IMAGE> R6 is hydrogen or lower alkyl; R7 is hydrogen, lower alkyl, <IMAGE> or -(CH2)n-N-(lower alkyl)2; R8 is hydrogen, sodium or potassium; n is an integer from 1 to 4; are disclosed. These compounds are useful as antibacterial agents.
Inventors
- 👤 Christopher M. Cimarusti
- 👤 William H. Koster
- 👤 Richard B. Sykes
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 23:21
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/02; C07D209/44; C07D209/48; A; A61; A61P; A61P31/00; A61P31/04; C07D277/00; C07D277/02; C07D277/20; C07D277/587; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/55
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
40 words
A compound of the formula: ##STR111## including its imino tautomeric form wherein the ##STR112## group is in the syn configuration; the sulfoxide is in the β-configuration; R is hydrogen, sodium or potassium; and R 4 is hydrogen, sodium or potassium.
Claim 2
Dependent Claim
40 words
A compound of the formula: ##STR111## including its imino tautomeric form wherein the ##STR112## group is in the syn configuration; the sulfoxide is in the β-configuration; R is hydrogen, sodium or potassium; and R 4 is hydrogen, sodium or potassium.
Claim 3
Dependent Claim
8 words
The compound of claim 1, [5S-[5α,6β,7α-(Z)]]-3-[(acetyloxy)methyl]-7-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 5-oxide.
Claim 4
Dependent Claim
9 words
The disodium salt of the compound of claim 2.
Claim 5
Dependent Claim
19 words
An antibacterial pharmaceutical composition comprising a pharmaceutically acceptable carrier and one or more antibacterially active compounds of claim 1.
Claim 6
Dependent Claim
24 words
The method of combating infections in mammals caused by gram-negative microorganisms which comprises parenterally administering an effective amount of the composition of claim 4.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-02 | 1984-06-02 | 1984-12-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-02 | 1988-06-02 | 1988-12-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-02 | 1992-06-02 | 1992-12-02 | $7700.00 | Window Closed / Lapsed |