US4084049A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Cepham derivatives
Assignee: Astellas Pharma Inc
•
Filing: 1976-01-12
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Granted: 1978-04-11
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Expires: 1996-01-12
Abstract
Abstract A compound of the formula <IMAGE> wherein R' is amino or a conventional, pharmaceutically acceptable acylamino, R2 is carboxy or a conventionally protected carboxy, X is -S- or <IMAGE> R3 is lower alkyl and Y'' is a residue of a strong nucleophile selected from the group consisting of azido and arylamino.
Inventors
- 👤 Takashi Kamiya
- 👤 Tsutomu Teraji
- 👤 Masashi Hashimoto
- 👤 Osamu Nakaguti
- 👤 Teruo Oku
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 15:53
CPC Classifications
C; C07; C07D; C07D499/00; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07D205/09; C07D205/095
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
63 words
A compound of the general formula: ##STR261## wherein R 1 is a conventional, pharmaceutically acceptable acylamino, R 2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR262## R 3 is lower alkyl and Y" is a residue of a strong nucleophile selected from the group consisting of azido and arylamino, wherein said arylamino is anilino, toluidino, nitroanilino, nitrotoluidino, or naphthylamino.
Claim 2
Dependent Claim
63 words
A compound of the general formula: ##STR261## wherein R 1 is a conventional, pharmaceutically acceptable acylamino, R 2 is carboxy or a conventionally protected carboxy, X is --S-- or ##STR262## R 3 is lower alkyl and Y" is a residue of a strong nucleophile selected from the group consisting of azido and arylamino, wherein said arylamino is anilino, toluidino, nitroanilino, nitrotoluidino, or naphthylamino.
Claim 3
Dependent Claim
37 words
The compound according to claim 1, in which R 1 is phenyl (lower)alkanoylamino or phenoxy(lower)alkanoylamino, R 2 is carboxy, lower alkoxycarbonyl or trihalo(lower)alkoxycarbonyl, R 3 is lower alkyl, X is --S-- and Y" is azido or anilino.
Claim 4
Dependent Claim
27 words
The compound according to claim 2, in which R 1 is phenylacetamido or phenoxyacetamido, R 2 is carboxy, methoxycarbonyl, 1-cyclopropylethoxycarbonyl or 2,2,2-trichloroethoxycarbonyl, and R 3 is methyl.
Claim 5
Dependent Claim
10 words
The compound according to claim 3, which is 2,2,2-trichloroethyl 3-azido-3-methyl-7-(2-phenylacetamido)cephem-4-carboxylate.
Claim 6
Dependent Claim
10 words
The compound according to claim 3, which is 3-anilino-3-methyl-7-(2-phenoxyacetamido)cephem-4-carboxylic acid.
Claim 7
Dependent Claim
10 words
The compound according to claim 3, which is methyl 3-anilino-3-methyl-7-(2-phenylacetamido)cepham-4-carboxylate.
Claim 8
Dependent Claim
10 words
The compound according to claim 3, which is methyl 3-anilino-3-methyl-7-(2-phenoxyacetamido)cepham-4-carboxylate.
Claim 9
Dependent Claim
10 words
The compound according to claim 3, which is 2,2,2-trichloroethyl 3-anilino-3-methyl-7-(2-phenylacetamido)cepham-4-carboxylate.
Claim 10
Dependent Claim
10 words
The compound according to claim 3, which is 2,2,2-trichloroethyl 3-anilino-3-methyl-7-(2-phenoxyacetamido)cepham-4-carboxylate.
Claim 11
Dependent Claim
10 words
The compound according to claim 3, which is 1-cyclopropylethyl 3-anilino-3-methyl-7-(2-phenylacetamido)cepham-4-carboxylate.
Claim 12
Dependent Claim
10 words
The compound according to claim 3, which is 1-cyclopropylethyl 3-anilino-3-methyl-7-(2-phenoxyacetamido)cepham-4-carboxylate.
References Cited (Backward Citations)
US3993646A
Cited
US3954732A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-04-10 | 1981-10-10 | 1982-04-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-04-10 | 1985-10-10 | 1986-04-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-04-10 | 1989-10-10 | 1990-04-11 | $7700.00 | Window Closed / Lapsed |