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US4237068A Expired / Lapsed US ⏱️ 0.0 years remaining

Primary aminoacylanilides

Assignee: Astra USA Inc
•
Filing: 1978-08-01
•
Granted: 1980-12-02
•
Expires: 1998-08-01
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Abstract

Abstract Primary amino acylanilides of the formula <IMAGE> wherein R1 is selected from the group consisting of hydrogen, methyl, ethyl and propyl, R2 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R3 is selected from the group consisting of hydrogen and methyl, R4 is selected from the group consisting of hydrogen, methyl, and a C1-C4 alkoxy group, R6 is selected from the group consisting of methyl, ethyl, chlorine, methoxy and ethoxy, R7 is hydrogen, methyl or ethyl, R8 is hydrogen, R9 is hydrogen, methyl or ethyl, R10 is hydrogen, and n is 0 or 1, with the provisions that (a) when n is 0, R8 can also be methyl; (b) when n is 1, and R7 is hydrogen, and R9 is hydrogen or methyl, then R10 can also be methyl; (c) when R1 is hydrogen, R2 is methyl, R3 is hydrogen, R6 is methyl, R7 is hydrogen, R8 is hydrogen, and n is 0, then R4 can be ethoxy or propoxy only; (d) when R1 is hydrogen, R2 is methyl, R3, R4, R7 and R8 are hydrogen, and n is 0, then R6 is methoxy, ethoxy, or ethyl only; and the therapeutically acceptable salts thereof. Compounds of this type have been found to be effective longlasting cardiac antiarrhythmic agents, especially when administered by the oral route.

Inventors

  • 👤 Robert N. Boyes
  • 👤 Benjamin R. Duce
  • 👤 Emil R. Smith
  • 👤 Eugene W. Byrnes

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-02 21:46
CPC Classifications
C; C09; C09B; C09B27/00

Claims Analysis

Total Claims: 28
Claim 1
Independent Claim 9 words
The compound 2-amino-2',6'-propionoxylidide, and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim 9 words
The compound 2-amino-2',6'-propionoxylidide, and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim 9 words
The compound (+)-2-amino-2',6'-propionoxylidide, and the pharmaceutically acceptable salts thereof.
Claim 4
Dependent Claim 9 words
The compound (+)-2-amino-2',6'-propionoxylidide, and the pharmaceutically acceptable salts thereof.
Claim 5
Dependent Claim 9 words
The compound (-)-2-amino-2',6'-propionoxylidide, and the pharmaceutically acceptable salts thereof.
Claim 6
Dependent Claim 9 words
The compound (-)-2-amino-2',6'-propionoxylidide, and the pharmaceutically acceptable salts thereof.
Claim 7
Dependent Claim 9 words
The compound 2-amino-2'-ethyl-6'-methylpropionanilide, and the pharmaceutically acceptable salts thereof.
Claim 8
Dependent Claim 9 words
The compound 2-amino-2'-ethyl-6'-methylpropionanilide, and the pharmaceutically acceptable salts thereof.
Claim 9
Dependent Claim 9 words
The compound 3-amino-2',6'-butyroxylidide, and the pharmaceutically acceptable salts thereof.
Claim 10
Dependent Claim 9 words
The compound 3-amino-2',6'-butyroxylidide, and the pharmaceutically acceptable salts thereof.
Claim 11
Dependent Claim 9 words
The compound 2-amino-2',6'-diethylpropionanilide, and the pharmaceutically acceptable salts thereof.
Claim 12
Dependent Claim 9 words
The compound 2-amino-2',6'-diethylpropionanilide, and the pharmaceutically acceptable salts thereof.
Claim 13
Dependent Claim 9 words
The compound 3-amino-2',4',6'-propionomesidide, and the pharmaceutically acceptable salts thereof.
Claim 14
Dependent Claim 9 words
The compound 3-amino-2',4',6'-propionomesidide, and the pharmaceutically acceptable salts thereof.
Claim 15
Dependent Claim 9 words
The compound 2-amino-4'-butoxy-2',6'-dimethylpropionanilide, and the pharmaceutically acceptable salts thereof.
Claim 16
Dependent Claim 9 words
The compound 2-amino-4'-butoxy-2',6'-dimethylpropionanilide, and the pharmaceutically acceptable salts thereof.
Claim 17
Dependent Claim 9 words
The compound 3-amino-2'-methyl-6'-ethylbutyranilide, and the pharmaceutically acceptable salts thereof.
Claim 18
Dependent Claim 9 words
The compound 3-amino-2'-methyl-6'-ethylbutyranilide, and the pharmaceutically acceptable salts thereof.
Claim 19
Dependent Claim 9 words
The compound 3-amino-2',4',6'-butyromesidide, and the pharmaceutically acceptable salts thereof.
Claim 20
Dependent Claim 9 words
The compound 3-amino-2',4',6'-butyromesidide, and the pharmaceutically acceptable salts thereof.
Claim 21
Dependent Claim 9 words
The compound 3-amino-2',6'-valeroxylidide, and the pharmaceutically acceptable salts thereof.
Claim 22
Dependent Claim 9 words
The compound 3-amino-2',6'-valeroxylidide, and the pharmaceutically acceptable salts thereof.
Claim 23
Dependent Claim 9 words
The compound 3-amino-2',6'-propionoxylidide and the pharmaceutically acceptable salts thereof.
Claim 24
Dependent Claim 9 words
The compound 3-amino-2',6'-propionoxylidide and the pharmaceutically acceptable salts thereof.
Claim 25
Dependent Claim 9 words
The compound 2-amino-2',6'-butyroxylidide and the pharmaceutically acceptable salts thereof.
Claim 26
Dependent Claim 9 words
The compound 2-amino-2',6'-butyroxylidide and the pharmaceutically acceptable salts thereof.
Claim 27
Dependent Claim 9 words
The compound 3-amino-2-methyl-2',6'-propionoxylidide and the pharmaceutically acceptable salts thereof.
Claim 28
Dependent Claim 9 words
The compound 3-amino-2-methyl-2',6'-propionoxylidide and the pharmaceutically acceptable salts thereof.

References Cited (Backward Citations)

GB726080A Cited
US2851393A Cited
US2794835A Cited
GB809286A Cited
US2904586A Cited
US3160662A Cited
US2948736A Cited
US3268577A Cited
US3542850A Cited
US3812147A Cited
US4080452A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1983-12-02 1984-06-02 1984-12-02 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1987-12-02 1988-06-02 1988-12-02 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1991-12-02 1992-06-02 1992-12-02 $7700.00 Window Closed / Lapsed

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