US4080452A
Expired / Lapsed
US
⏱️ 0.0 years remaining
N-acyl anilines, useful for gastro-enterological disorders
Assignee: Science Union et Cie
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Filing: 1976-02-09
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Granted: 1978-03-21
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Expires: 1996-02-09
Abstract
Abstract This invention relates to novel N-acyl anilines, to a process for their preparation and to pharmaceutical compositions containing them. The N-acyl anilines are obtained by condensing a substituted aniline with an aminolower alkyl carboxylic acid or a functional derivative thereof. The compounds of the invention have therapeutic utility namely in the gastro-enterologic field.
Inventors
- 👤 Charles Malen
- 👤 Pierre Roger
- 👤 Xavier Pascaud
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 23:27
CPC Classifications
C; C07; C07D; C07D207/00; C07D207/02; C07D207/04; C07D207/08; A; A61; A61P; A61P1/00; A61P1/04; C07C; C07C255/00; C07D211/00; C07D211/04; C07D211/06; C07D211/08; C07D211/18; C07D211/34; C07D295/00; C07D295/04; C07D295/14; C07D295/145; C07D295/15
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
107 words
A member of the group consisting of a compound of the formula ##STR11## wherein: m is 0 or an integer of 1 to 5 R is hydrogen or lower alkyl of 1 to 6 carbon atoms in the chain; R 1 is lower alkyl of 1 to 6 carbon atoms, lower alkenyl of 1 to 6 carbon atoms, lower cycloalkyl of 3 to 7 ring carbon atoms or phenyl lower alkyl of 1 to 6 carbon atoms in the side chain; R 2 is cyano, trifluoromethyl or lower alkanoyl of 1 to 6 carbon atoms; and the acid addition addition salts thereof with organic or mineral acids.
Claim 2
Dependent Claim
107 words
A member of the group consisting of a compound of the formula ##STR11## wherein: m is 0 or an integer of 1 to 5 R is hydrogen or lower alkyl of 1 to 6 carbon atoms in the chain; R 1 is lower alkyl of 1 to 6 carbon atoms, lower alkenyl of 1 to 6 carbon atoms, lower cycloalkyl of 3 to 7 ring carbon atoms or phenyl lower alkyl of 1 to 6 carbon atoms in the side chain; R 2 is cyano, trifluoromethyl or lower alkanoyl of 1 to 6 carbon atoms; and the acid addition addition salts thereof with organic or mineral acids.
Claim 3
Dependent Claim
16 words
The acid addition salts of a compound of claim 1 with a mineral or organic acid.
Claim 4
Dependent Claim
7 words
1-morpholinyl propionylamino)-2-methoxy-5-cyano benzene according to claim 1.
Claim 5
Dependent Claim
34 words
A composition active in inhibiting both gastric secretion and delay in gastric evacuation containing an inhibitorily effective amount of at least one compound of claim 1 in association with a pharmaceutical carrier or diluent.
Claim 6
Dependent Claim
21 words
A composition as claimed in claim 4 in any of the forms suitable for oral, parenteral, rectal, perlingual or percutaneous administration.
Claim 7
Dependent Claim
19 words
A composition as claimed in claim 4 containing from 10 to 200 mg of active ingredient per dosage unit.
Claim 8
Dependent Claim
35 words
A method of inhibiting gastric hypersecretion and delay in gastric evacuation which comprises administering to warm-blooded animals suffering or disposed to suffer from said ailment an inhibitorily effective amount of a compound of claim 1.
Claim 9
Dependent Claim
18 words
The method of claim 7 wherein the amount ranges from 0.3 to 6 mg/kg body weight per day.
References Cited (Backward Citations)
US2912460A
Cited
US3989834A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-20 | 1981-09-19 | 1982-03-21 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-20 | 1985-09-19 | 1986-03-21 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-20 | 1989-09-19 | 1990-03-21 | $7700.00 | Window Closed / Lapsed |