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US4235909A
Expired / Lapsed
US
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Octahydro-2H-pyrrolo[3,4-g]quinolines
Assignee: Eli Lilly and Co
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Filing: 1979-04-19
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Granted: 1980-11-25
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Expires: 1999-04-19
Abstract
Abstract Octahydro-2H-pyrrolo[3,4-g]quinolines, useful as dopamine agonists, particularly as inhibitors of prolactin secretion and in treatment of Parkinsonism.
Inventors
- 👤 Nicholas J. Bach
- 👤 Edmund C. Kornfeld
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 19:30
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/22; C07D215/227; C07D471/00; C07D471/02; C07D471/04
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
46 words
A compound of the formula ##STR7## wherein R 1 is H, (C 1 -C 3 )alkyl-CO, or (C 1 -C 3 )alkyl, R 2 is H, C 1 -C 3 alkyl, allyl or benzyl and R 3 is H, or a pharmaceutically-acceptable acid addition salt thereof.
Claim 2
Dependent Claim
46 words
A compound of the formula ##STR7## wherein R 1 is H, (C 1 -C 3 )alkyl-CO, or (C 1 -C 3 )alkyl, R 2 is H, C 1 -C 3 alkyl, allyl or benzyl and R 3 is H, or a pharmaceutically-acceptable acid addition salt thereof.
Claim 3
Dependent Claim
40 words
A compound according to claim 1 in which R 1 is H or (C 1 -C 3 )alkyl, R 2 is (C 1 -C 3 )alkyl or allyl and R 3 is H or a pharmaceutically-acceptable acid addition salt thereof.
Claim 4
Dependent Claim
21 words
A compound according to claim 1 in which R 2 is H or benzyl or a pharmaceutically-acceptable acid addition salt thereof.
Claim 5
Dependent Claim
10 words
A compound according to claim 2 said compound being trans-dl-5-n-propyl-4,4a,5,6,7,8,8a,9-octahydro-2H-pyrrolo[3,4-g]quinoline
Claim 6
Dependent Claim
10 words
A compound according to claim 3, said compound being trans-dl-4,4a,5,6,7,8,8a,9-octahydro-2H-pyrrolo[3,4-g]quinoline.
Claim 7
Dependent Claim
9 words
A maleate salt of the racemate of claim 5.
Claim 8
Dependent Claim
9 words
A maleate salt of the racemate of claim 4.
Claim 9
Dependent Claim
43 words
A method of treating Parkinson's Syndrome which consists of administration to a mammal suffering from Parkinson's Syndrome and in need of treatment, a dose of a compound according to claim 2 effective to alleviate some or all of the manifestations of Parkinson's Syndrome.
Claim 10
Dependent Claim
49 words
A method of inhibiting the secretion of prolactin in mammals which consists of administering to a mammal having a condition in which there is an excess of prolactin being secreted, and in need of treatment, a dose of a compound according to claim 2 effective to reduce prolactin secretion.
Claim 11
Dependent Claim
41 words
A pharmaceutical composition in unit dosage form adapted for administration to achieve a prolactin inhibiting effect, comprising per dosage unit, an amount of a compound according to claim 2 sufficient to inhibit the secretion or prolactin and a standard pharmaceutical excipient.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-25 | 1984-05-26 | 1984-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-25 | 1988-05-26 | 1988-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-25 | 1992-05-26 | 1992-11-25 | $7700.00 | Window Closed / Lapsed |