US4235881A
Expired / Lapsed
US
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Method for producing high potency factor VIII
Assignee: Ferring Pharmaceuticals Inc
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Filing: 1978-12-04
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Granted: 1980-11-25
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Expires: 1998-12-04
Abstract
Abstract Factor VIII preparations of enhanced potency are obtained from human blood donors by recovering blood from donors who have been treated with vasopressin analogs, such as 1-deamino-6-carba-8-D-arginine vasopressin, in an amount sufficient to increase the circulating blood level of Factor VIII in the donor.
Inventors
- 👤 Joseph H. Cort
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 21:18
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A; A61; A61K; A61K38/00; A61K38/04; A61K38/08; A61K38/095; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83; Y10S930/00; Y10S930/01; Y10S930/15
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
135 words
In a method for producing a Factor VIII preparation comprising collecting blood from a donor, separating the plasma therefrom, and recovering a Factor VIII-rich fraction from said plasma, the improvement of administering to said donor, in an amount effective to increase the circulating level of Factor VIII in the blood of said donor, a polypeptide represented by the formula: ##STR2## wherein W is hydrogen, hydroxy or amino; Y is a residue of an alpha-amino acid having a basic aliphatic side chain in the D-configuration containing from 2 to 5 carbon atoms and having on the terminal carbon a basic group; and Z is disulfide or monocarba, with the proviso that when W is hydroxy, and Y is the D-arginine residue, then Z is monocarba, and thereafter recovering blood containing said increased levels of Factor VIII.
Claim 2
Dependent Claim
135 words
In a method for producing a Factor VIII preparation comprising collecting blood from a donor, separating the plasma therefrom, and recovering a Factor VIII-rich fraction from said plasma, the improvement of administering to said donor, in an amount effective to increase the circulating level of Factor VIII in the blood of said donor, a polypeptide represented by the formula: ##STR2## wherein W is hydrogen, hydroxy or amino; Y is a residue of an alpha-amino acid having a basic aliphatic side chain in the D-configuration containing from 2 to 5 carbon atoms and having on the terminal carbon a basic group; and Z is disulfide or monocarba, with the proviso that when W is hydroxy, and Y is the D-arginine residue, then Z is monocarba, and thereafter recovering blood containing said increased levels of Factor VIII.
Claim 3
Dependent Claim
20 words
A method according to claim 1 wherein said amount is a circulating drug dosage of at least about 10 micrograms.
Claim 4
Dependent Claim
19 words
A method according to claim 2 wherein W is hydroxy, Y is the D-arginine residue and Z is monocarba.
Claim 5
Dependent Claim
22 words
A method according to claim 3 wherein said amount is a circulating drug dosage of from about 10 to about 20 micrograms.
Claim 6
Dependent Claim
11 words
A method according to claim 2 wherein said administration is intravenously.
Claim 7
Dependent Claim
11 words
A method according to claim 2 wherein said administration is intranasally.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-25 | 1984-05-26 | 1984-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-25 | 1988-05-26 | 1988-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-25 | 1992-05-26 | 1992-11-25 | $7700.00 | Window Closed / Lapsed |