Patent US4234585A successfully refreshed from Google Patents.
US4234585A
Expired / Lapsed
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1,2-Dihydroquinoline-2-one derivatives
Assignee: Roche Diagnostics GmbH
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Filing: 1979-06-04
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Granted: 1980-11-18
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Expires: 1999-06-04
Abstract
Abstract A (4-substituted-piperazin-1-yl)-alkoxy-2-oxo-1,2-dihydroquinoline of the formula: <IMAGE> in which R1, R2 and R3 each independently is hydrogen or a lower alkyl radical, R4 is hydrogen, halogen, or a lower alkyl or lower alkoxy radical, n is 2, 3, 4 or 5 and A is a valency bond or a methylene radical optionally substituted by a phenyl radical, or a salt thereof, which exhibits anti-allergic and anti-hypertensive activity.
Inventors
- 👤 Werner Winter
- 👤 Walter-Gunar Friebe
- 👤 Wolfgang Kampe
- 👤 Androniki Roesch
- 👤 Otto-Henning Wilhelms
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 16:31
CPC Classifications
C; C07; C07D; C07D215/00; C07D215/02; C07D215/16; C07D215/20; C07D215/22; C07D215/227; A; A61; A61P; A61P37/00; A61P37/08; C07D215/24; C07D215/26
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
77 words
A (4-substituted-piperazin-1-yl)-alkoxy-2-oxo-1,2-dihydroquinoline of the formula: ##STR7## in which R 1 , R 2 and R 3 each independently is hydrogen or an alkyl radical with 1 to 6 carbon atoms, R 4 is hydrogen, halogen, or an alkyl or alkoxy radical with 1 to 6 carbon atoms, n is 2, 3, 4 or 5 and A is a valency bond or a methylene radical optionally substituted by phenyl, or a salt thereof with a pharmacologically acceptable acid.
Claim 2
Dependent Claim
77 words
A (4-substituted-piperazin-1-yl)-alkoxy-2-oxo-1,2-dihydroquinoline of the formula: ##STR7## in which R 1 , R 2 and R 3 each independently is hydrogen or an alkyl radical with 1 to 6 carbon atoms, R 4 is hydrogen, halogen, or an alkyl or alkoxy radical with 1 to 6 carbon atoms, n is 2, 3, 4 or 5 and A is a valency bond or a methylene radical optionally substituted by phenyl, or a salt thereof with a pharmacologically acceptable acid.
Claim 3
Dependent Claim
47 words
A compound or salt thereof according to claim 1, in which R 1 , R 2 and R 3 each independently is hydrogen or alkyl with 1 to 4 carbon atoms, and R 4 is hydrogen, chlorine, or alkyl or alkoxy with 1 to 4 carbon atoms.
Claim 4
Dependent Claim
18 words
A compound or salt thereof according to claim 1, wherein such compound is 4-methyl-7-{3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline of the formula ##STR8##
Claim 5
Dependent Claim
18 words
A compound or salt thereof according to claim 1, wherein such compound is 4-methyl-6-{3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline of the formula ##STR9##
Claim 6
Dependent Claim
18 words
A compound or salt thereof according to claim 1, wherein such compound is 4-methyl-7-[3-(4-benzylpiperazin-1-yl)-propoxy]-2-oxo-1,2-dihydroquinoline of the formula ##STR10##
Claim 7
Dependent Claim
18 words
A compound or salt thereof according to claim 1, wherein such compound is 3-n-butyl-4-methyl-7-{3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline of the formula ##STR11##
Claim 8
Dependent Claim
29 words
An anti-allergic and anti-hypertensive composition of matter comprising an anti-allergically anti-hypertensive effective amount of a compound or salt according to claim 1 in admixture with a pharmacologically acceptable diluent.
Claim 9
Dependent Claim
33 words
A method of reducing an allergic or hypertensive condition in a patient which comprises administering to such patient an anti-allergically or anti-hypertensive effective amount of a compound or salt according to claim 1.
Claim 10
Dependent Claim
15 words
The method according to claim 8, wherein said compound is 4-methyl-7-{3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline, 4-methyl-6-{3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline, 4-methyl-7-[3-(4-benzylpiperazin-1-yl)-propoxy]-2-oxo-1,2-dihydroquinoline, or 3-n-butyl-4-methyl-7-{3-[4-(4-chlorobenzyl)-piperazin-1-yl]-propoxy}-2-oxo-1,2-dihydroquinoline.
References Cited (Backward Citations)
DE1932384A1
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-18 | 1984-05-19 | 1984-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-18 | 1988-05-19 | 1988-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-18 | 1992-05-19 | 1992-11-18 | $7700.00 | Window Closed / Lapsed |