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US4234499A
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Cis-diammireplatinum(II) organophosphate complexes
Assignee: Engelhard Minerals and Chemicals Corp
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Filing: 1979-03-07
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Granted: 1980-11-18
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Expires: 1999-03-07
Abstract
Abstract Cis-diammineplatinum(II) organophosphate complexes where the organophosphate moiety is a glycerophosphate or a monosaccharide phosphate moiety are prepared by reaction of cis-diaquodiammineplatinum(II) salts with alkali metal organophosphates. The resulting complexes possess pronounced anti-tumor activity in mice and low toxicity; consequently, they have high therapeutic indices.
Inventors
- 👤 James D. Hoeschele
- 👤 Alan R. Amundsen
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 04:20
CPC Classifications
C; C07; C07F; C07F15/00; C07F15/0006; C07F15/0086; C07F15/0093; A; A61; A61P; A61P35/00; C07F9/00; C07F9/02; C07F9/06; C07F9/08; C07F9/09; C07F9/091
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
65 words
A platinum(II) organophosphate complex of the formula: [Pt(NH.sub.3).sub.2 (R.sup.1 (OPO.sub.3).sub.z).sub.y ] in which R 1 (OPO 3 ) z is an organophosphate moiety where R 1 is selected from the group consisting of the monovalent residue of glycerol and the monovalent and divalent residues of a monosaccharide, and y is an integer having a value of from about 0.4-0.9 and z is 1 or 2.
Claim 2
Dependent Claim
65 words
A platinum(II) organophosphate complex of the formula: [Pt(NH.sub.3).sub.2 (R.sup.1 (OPO.sub.3).sub.z).sub.y ] in which R 1 (OPO 3 ) z is an organophosphate moiety where R 1 is selected from the group consisting of the monovalent residue of glycerol and the monovalent and divalent residues of a monosaccharide, and y is an integer having a value of from about 0.4-0.9 and z is 1 or 2.
Claim 3
Dependent Claim
26 words
A complex according to claim 1 wherein the organophosphate moiety is selected from the group consisting of α-D,L-glycerophosphate, β-glycerophosphate, α-D-glucose-1-phosphate, D-glucose-6-phosphate, D-fructose-6-phosphate, D-galactose-6-phosphate, D-ribose-5-phosphate, and D-fructose-1,6-diphosphate.
Claim 4
Dependent Claim
12 words
A complex according to claim 1 wherein said organophosphate moiety is α-D,L-glycerophosphate.
Claim 5
Dependent Claim
12 words
A complex according to claim 1 wherein said organophosphate moiety is β-glycerophosphate.
Claim 6
Dependent Claim
12 words
A complex according to claim 1 wherein said organophosphate moeity is α-D-glucose-1-phosphate.
Claim 7
Dependent Claim
12 words
A complex according to claim 1 wherein said organophosphate moeity is D-glucose-6-phosphate.
Claim 8
Dependent Claim
12 words
A complex according to claim 1 wherein said organophosphate moeity is D-fructose-6-phosphate.
Claim 9
Dependent Claim
12 words
A complex according to claim 1 wherein said oganophosphate moeity is D-galactose-6-phosphate.
Claim 10
Dependent Claim
12 words
A complex according to claim 1 wherein said organophosphate moeity is D-ribose-5-phosphate.
Claim 11
Dependent Claim
11 words
A complex according to claim 1 wherein said organophosphate is D-fructose-1,6-diphosphate.
References Cited (Backward Citations)
US3759896A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-18 | 1984-05-19 | 1984-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-18 | 1988-05-19 | 1988-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-18 | 1992-05-19 | 1992-11-18 | $7700.00 | Window Closed / Lapsed |