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Patent US4234477A successfully refreshed from Google Patents.
US4234477A
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α-N-Acetyl-L-phenylalanyl-L-arginine ethyl ester
Assignee: Bayer AG
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Filing: 1979-03-08
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Granted: 1980-11-18
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Expires: 1999-03-08
Abstract
Abstract The new compound acetylphenylalanyl-arginine ethyl ester (Ac-Phe-Arg OEt) and its acid addition salts are used in the diagnostic determination of the content of Kallikrein. In view of the role of Kallikrein in regulating blood pressure or the renal function, the reliable determination of small amounts of Kallikrein such as occur in urine, saliva or glands is important but has been difficult to achieve. Ac-Phe-Arg OEt and its esters provide a substrate for use in such determinations and allow a significant improvement in accuracy.
Inventors
- 👤 Franz Fiedler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 09:05
CPC Classifications
C; C12; C12Q; C12Q1/00; C12Q1/34; C12Q1/37; C07; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06078; G; G01; G01N; G01N2333/00; G01N2333/90; G01N2333/914; G01N2333/948; G01N2333/95; G01N2333/964; G01N2333/96425; G01N2333/96427; G01N2333/9643; G01N2333/96433; G01N2333/96441; G01N2333/96455
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
9 words
Acetylphenylalanyl-arginine ethyl ester or an acid addition salt thereof.
Claim 2
Dependent Claim
9 words
Acetylphenylalanyl-arginine ethyl ester or an acid addition salt thereof.
Claim 3
Dependent Claim
45 words
A process for the diagnostic determination of small amounts of Kallikrein which comprises adding Kallikrein in a liquid medium to a substrate of acetylphenylalanyl-arginine ethyl ester or an acid addition salt thereof and determining the Kallikrein content therefrom by measuring liberated ethanol or carboxylic groups.
Claim 4
Dependent Claim
45 words
A process for the diagnostic determination of small amounts of Kallikrein which comprises adding Kallikrein in a liquid medium to a substrate of acetylphenylalanyl-arginine ethyl ester or an acid addition salt thereof and determining the Kallikrein content therefrom by measuring liberated ethanol or carboxylic groups.
Claim 5
Dependent Claim
17 words
A process according to claim 2, in which diagnostic determination is of the Kallikrein content in urine.
Claim 6
Dependent Claim
17 words
A process according to claim 2, in which diagnostic determination is of the Kallikrein content in saliva.
Claim 7
Dependent Claim
17 words
A process according to claim 2, in which diagnostic determination is of the Kallikrein content in glands.
Claim 8
Dependent Claim
11 words
A process of claim 2 wherein the liberated ethanol is measured.
Claim 9
Dependent Claim
12 words
A process of claim 2 wherein the liberated carboxylic groups are measured.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-18 | 1984-05-19 | 1984-11-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-18 | 1988-05-19 | 1988-11-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-18 | 1992-05-19 | 1992-11-18 | $7700.00 | Window Closed / Lapsed |