US4233286A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Low affinity IGM-latex particles and assay therewith for immune complexes
Assignee: National Research Development Corp UK
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Filing: 1977-09-09
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Granted: 1980-11-11
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Expires: 1997-09-09
Abstract
Abstract A method for the estimation of an immune complex and analysis of a constituent thereof comprising a latex particle agglutination test, in which a sample containing immune complex is incubated with latex particles coated with low affinity non-human antibodies to said complex constituent.
Inventors
- 👤 John F. Soothill
- 👤 Roland J. Levinsky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-24 23:09
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/564; Y; Y10; Y10S; Y10S436/00; Y10S436/821; Y10S530/00; Y10S530/863; Y10S530/868
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
52 words
A method for the estimation of a human immune complex and analysis of an antibody constituent thereof comprising a latex particle agglutination test, in which a sample containing human immune complex is incubated with latex particles coated with low affinity IgM antibodies raised in a non-human animal against said human anitbody constituent.
Claim 2
Independent Claim
52 words
A method for the estimation of a human immune complex and analysis of an antibody constituent thereof comprising a latex particle agglutination test, in which a sample containing human immune complex is incubated with latex particles coated with low affinity IgM antibodies raised in a non-human animal against said human anitbody constituent.
Claim 3
Dependent Claim
20 words
A method according to claim 1, in which the complex constituent undergoing analysis is an immunoglobulin constituent of said complex.
Claim 4
Dependent Claim
11 words
A method according to claim 1, comprising a slide agglutination test.
Claim 5
Dependent Claim
22 words
A method according to claim 1, in which, subsequent to incubation, agglutination is monitored by means of an electronic particle counting apparatus.
Claim 6
Dependent Claim
17 words
The method of claim 1 wherein said human immune complex is from a sample of human blood.
Claim 7
Dependent Claim
17 words
The method of claim 1 wherein said human immune complex is from a sample of human urine.
Claim 8
Dependent Claim
22 words
A latex particle product coated with immunoglobulins consisting of low affinity IgM antibodies raised in a non-human animal against a human antibody.
Claim 9
Dependent Claim
22 words
A latex particle product coated with immunoglobulins consisting of low affinity IgM antibodies raised in a non-human animal against a human antibody.
Claim 10
Dependent Claim
16 words
The product of claim 7 wherein said latex particles have a dimeter of about 1.15 μm.
Claim 11
Dependent Claim
12 words
The product of claim 7 wherein said human antibody is human IgA.
Claim 12
Dependent Claim
12 words
The product of claim 7 wherein said human antibody is human IgG.
Claim 13
Dependent Claim
12 words
The product of claim 7 wherein said human antibody is human IgM.
Claim 14
Dependent Claim
28 words
The product of claim 7 wherein said non-human IgM antibodies are extracted from an animal selected from the group consisting of rabbits, guinea pigs, sheep, cows and horses.
Claim 15
Dependent Claim
11 words
The product of claim 12 wherein said animal is a rabbit.
Claim 16
Dependent Claim
12 words
The product of claim 12 wherein said animal is a guinea pig.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-11 | 1984-05-12 | 1984-11-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-11 | 1988-05-12 | 1988-11-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-11 | 1992-05-12 | 1992-11-11 | $7700.00 | Window Closed / Lapsed |