US4233144A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Electrode for voltammetric immunoassay
Assignee: Bayer Corp
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Filing: 1979-04-16
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Granted: 1980-11-11
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Expires: 1999-04-16
Abstract
Abstract Immunoassays featuring voltammetric measurements wherein at least one of the immunoreactants is labelled with an electroactive substance. Measurement is effectedon a pulsed-basis to maximize the signal change due to the electron transfer capabilities of the labelled immunoreactants.
Inventors
- 👤 Salvatore J. Pace
- 👤 Anand Kumar
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 14:33
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/531; G01N33/532; G01N27/00; G01N27/26; G01N27/28; G01N27/30; G01N27/327; G01N27/3275; G01N27/3277; G01N2458/00; G01N2458/30; Y; Y10; Y10S; Y10S436/00; Y10S436/806
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
28 words
A voltammetric monitoring electrode for measuring electrochemical changes resulting from an immunoreaction between complementing immunoreactants, said voltammetric monitoring electrode comprising an electroactively-labelled immunoreactant attached to a surface thereof.
Claim 2
Dependent Claim
28 words
A voltammetric monitoring electrode for measuring electrochemical changes resulting from an immunoreaction between complementing immunoreactants, said voltammetric monitoring electrode comprising an electroactively-labelled immunoreactant attached to a surface thereof.
Claim 3
Dependent Claim
22 words
The voltammetric monitoring electrode of claim 1, wherein said electroactively-labelled immunoreactant comprises at least one transition metal chelate linked to said immunoreactant.
Claim 4
Dependent Claim
35 words
The voltammetric monitoring electrode of claim 2, wherein said transition metal chelate consists of a metal chosen from a group of metals consisting of: Fe, Co, Cu, V, Zn, Cr, Mo, Cd, Mn, and Ni.
Claim 5
Dependent Claim
28 words
The voltammetric monitoring electrode of claim 2, wherein said transition metal chelate consists of a ligand chosen from a group of ligands consisting of: pyridyls, porphyrins, and pyridines.
Claim 6
Dependent Claim
45 words
An electroactively-labelled immunoreactant having more than one electroactive group attached thereto for the purpose of increasing the ability of the immunoreactant to transfer electrons at a surface of a monitoring electrode during a voltammetric immunossay, and hence, increase the sensitivity of measurement of said immunoreactant.
Claim 7
Dependent Claim
45 words
An electroactively-labelled immunoreactant having more than one electroactive group attached thereto for the purpose of increasing the ability of the immunoreactant to transfer electrons at a surface of a monitoring electrode during a voltammetric immunossay, and hence, increase the sensitivity of measurement of said immunoreactant.
Claim 8
Dependent Claim
17 words
The electroactively-labelled immunoreactant of claim 5 comprising at least one transition metal chelate linked to said immunoreactant.
Claim 9
Dependent Claim
34 words
The electroactively-labelled immunoreactant of claim 6, wherein said transition metal chelate consists of a metal chosen from a group of metals consisting of: Fe, Co, Cu, V, Zn, Cr, Mo, Cd, Mn, and Ni.
Claim 10
Dependent Claim
27 words
The electroactively-labelled immunoreactant of claim 6, wherein said transition metal chelate consists of a ligand chosen from a group of ligands consisting of: pyridyls, porphyrins, and pyridines.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-11 | 1984-05-12 | 1984-11-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-11 | 1988-05-12 | 1988-11-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-11 | 1992-05-12 | 1992-11-11 | $7700.00 | Window Closed / Lapsed |