US4151049A
Expired / Lapsed
US
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Compositions having protein reactive groups, membranes, electrodes coated with such compositions and chemical analysis methods
Assignee: Imperial Chemical Industries Ltd
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Filing: 1977-03-16
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Granted: 1979-04-24
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Expires: 1997-03-16
Abstract
Abstract A specifically reactive polymeric composition comprising an organic hydrophobic polymeric substrate with a specific protein reactive group pendant therefrom is disclosed. The protein reactive group is a free group of a hydrocarbon chain which has one end thereof absorbed into the surface of said substrate, said protein reactive group being bound to said hydrocarbon chain via an ionic group. An electrode coated with a layer of the specifically reactive composition provides, in conjunction with a reference electrode, an electrically sensitive system for measuring change in concentration of a compound in solution where said compound reacts selectively with the composition.
Inventors
- 👤 Jiri Janata
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 01:34
CPC Classifications
B; B01; B01D; B01D67/00; B01D67/0081; B01D67/0093; B01D67/00931; B01D15/00; B01D15/08; B01D15/26; B01D15/38; B01D15/3804; C; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54353; Y; Y10; Y10S; Y10S435/00; Y10S435/817
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
74 words
In a composition comprising a hydrophobic organic polymeric substrate having essentially hydrocarbon chains absorbed onto the surface thereof, said hydrocarbon chains having a group reactive with a protein attached thereto, the improvement which comprises as a protein reactive group an ionic protein bonding linkage to said hydrocarbon chains, said ionic linkage being derived from an imido ester of the formula ##STR4## where R is an alkyl group and X - is HCl or HBr.
Claim 2
Dependent Claim
74 words
In a composition comprising a hydrophobic organic polymeric substrate having essentially hydrocarbon chains absorbed onto the surface thereof, said hydrocarbon chains having a group reactive with a protein attached thereto, the improvement which comprises as a protein reactive group an ionic protein bonding linkage to said hydrocarbon chains, said ionic linkage being derived from an imido ester of the formula ##STR4## where R is an alkyl group and X - is HCl or HBr.
Claim 3
Dependent Claim
18 words
A composition according to claim 1 in which the linkage is derived from a methyl dodecyl imido ester.
Claim 4
Dependent Claim
17 words
A composition according to claim 1 in which the composition is in the form of a membrane.
Claim 5
Dependent Claim
22 words
A composition according to claim 1 in association with an electrode responsive to a change in the electrical charge of the composition.
Claim 6
Dependent Claim
19 words
A composition according to claim 1 in which the specific protein reactive group is an antibody or an antigen.
Claim 7
Dependent Claim
40 words
Apparatus comprising a composition according to claim 1 and means for detecting a change in the electrical potential associated with the said composition when it contacts a chemical substance reactive with the specific protein reactive group attached to said composition.
Claim 8
Dependent Claim
61 words
A method of detecting the presence of a chemical substance which comprises contacting the chemical substance with an electrode in association with the composition of claim 1, said composition being specifically reactive with the chemical substance and said electrode being responsive to a change in the electrical charge in said composition, and detecting any resultant change in the said electrical charge.
References Cited (Backward Citations)
US4000098A
Cited
US3966580A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-23 | 1982-10-23 | 1983-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-23 | 1986-10-23 | 1987-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-23 | 1990-10-23 | 1991-04-24 | $7700.00 | Window Closed / Lapsed |