Patent US4230702A successfully refreshed from Google Patents.
US4230702A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Readily enterally absorbable pharmaceutical compositions of per se poorly enterally absorbable pharmacologically active agents
Assignee: AbbVie Pharmaceuticals GmbH
•
Filing: 1978-01-09
•
Granted: 1980-10-28
•
Expires: 1998-01-09
Abstract
Abstract A readily enterally absorbable pharmaceutical composition of pharmacologically active agents, which per se are poorly enterally absorbable, is disclosed which comprises a pharmacologically, effective amount of at least one such pharmacologically active agent distributed in a vehicle comprising an absorption-enhancing amount of at least one partial glyceride of a fatty acid of long chain length. The preparation is suited for formulating cardiac glycosides, steroids, or anti-capillary fragility agents.
Inventors
- 👤 Theodor Eckert
- 👤 Fritz H. Kemper
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 05:01
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/56; A61K31/57
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
94 words
A readily enterally absorbable pharmaceutical composition of a per se poorly enterally absorbable pharmacologically-active agent selected from the group consisting of (1) a steroid selected from the group consisting of pregn-4-ene-3,20-dione or a pregna-4,6-diene-3,20-dione, gestagen and medrogestone and (2) an agent which is effective in improving the capillary strength comprising 2-ethyl-3-(4-hydroxybenzoyl) benzofuran, which comprises a pharmacologically effective amount of the pharmacologically-active agent distributed in a vehicle comprising an absorption enhancing amount of a glyceride selected from the group consisting of monoglycerides and diglycerides of oleic acid, stearic acid and palmitic acid and mixtures thereof.
Claim 2
Dependent Claim
94 words
A readily enterally absorbable pharmaceutical composition of a per se poorly enterally absorbable pharmacologically-active agent selected from the group consisting of (1) a steroid selected from the group consisting of pregn-4-ene-3,20-dione or a pregna-4,6-diene-3,20-dione, gestagen and medrogestone and (2) an agent which is effective in improving the capillary strength comprising 2-ethyl-3-(4-hydroxybenzoyl) benzofuran, which comprises a pharmacologically effective amount of the pharmacologically-active agent distributed in a vehicle comprising an absorption enhancing amount of a glyceride selected from the group consisting of monoglycerides and diglycerides of oleic acid, stearic acid and palmitic acid and mixtures thereof.
Claim 3
Dependent Claim
24 words
The composition as defined in claim 1, which comprises a solution of the per se poorly enterally absorbable pharmacologically active agent in the glyceride.
Claim 4
Dependent Claim
25 words
The composition as defined in claim 1, which comprises a microcrystalline suspension of the per se poorly enterally absorbable pharmacologically active agent in the glyceride.
Claim 5
Dependent Claim
22 words
The composition as defined in claim 1, wherein the per se poorly enterally absorbable pharmacologically active agent comprises one of said steroids.
Claim 6
Dependent Claim
17 words
The composition as defined in claim 4, wherein the steroid is a pregn-4-ene-3,20-dione or a pregna-4,6-diene-3, 20-dione.
Claim 7
Dependent Claim
13 words
The composition as defined in claim 4, wherein the steroid is a gestagen.
Claim 8
Dependent Claim
12 words
The composition as defined in claim 4, wherein the steroid is progesterone.
Claim 9
Dependent Claim
31 words
The composition as defined in claim 4, wherein the amount of the steroid per single dosage unit is about 1 to about 2 times the parenterally-effective amount of the respective steroid.
Claim 10
Dependent Claim
24 words
The composition as defined in claim 6, wherein the amount of the steroid per single dosage unit is between about 2 and 50 mg.
Claim 11
Dependent Claim
20 words
The composition as defined in claim 1, wherein the per se poorly enterally absorbable pharmacologically active agent comprises 2-ethyl-3-(4-hydroxybenzoyl) benzofuran.
Claim 12
Dependent Claim
25 words
The composition as defined in claim 10, wherein the amount of the active agent per single dosage unit is between about 25 and 100 mg.
Claim 13
Dependent Claim
24 words
The composition as defined in claim 1, wherein the amount of glycerides is between about 20 and about 100% by weight of the vehicle.
Claim 14
Dependent Claim
25 words
The composition as defined in claim 12, wherein the amount of the glycerides is from about 40 to about 100% by weight of the vehicle.
Claim 15
Dependent Claim
24 words
The composition as defined in claim 4, wherein the per weight ratio steroid/glyceride is of between about 5 to 100 and 0.5 to 100.
Claim 16
Dependent Claim
25 words
The composition as defined in claim 10, wherein the per weight ratio active agent/glyceride is of between about 10 to 100 and 1 to 100.
Claim 17
Dependent Claim
22 words
A method of capillary strengthening treatment which comprises enterally administering to a human being a pharmaceutical composition as defined in claim 10.
Claim 18
Dependent Claim
24 words
A method of treatment of steroid hormone deficiencies which comprises enterally administering to a human being a pharmaceutical composition as defined in claim 4.
Claim 19
Dependent Claim
12 words
The composition as defined in claim 4, wherein the steroid is medrogestone.
References Cited (Backward Citations)
US3514441A
Cited
GB1432784A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-28 | 1984-04-28 | 1984-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-28 | 1988-04-28 | 1988-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-28 | 1992-04-28 | 1992-10-28 | $7700.00 | Window Closed / Lapsed |