Patent US4230683A successfully refreshed from Google Patents.
US4230683A
Expired / Lapsed
US
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Hapten conjugated antibody for antibody or antigen detection
Assignee: Abbott Laboratories
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Filing: 1978-08-09
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Granted: 1980-10-28
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Expires: 1998-08-09
Abstract
Abstract The present invention encompasses an improved method for detecting antigen or antibody bound to a solid support which involves the reaction of hapten-labeled antibody to the antigen or antibody to be detected followed by reaction of the hapten moiety with labeled antibody to the hapten and the determination of the amount of label bound to the solid support.
Inventors
- 👤 Richard H. Decker
- 👤 Chung-Mei Ling
- 👤 Lacy R. Overby
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 12:16
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/543; G01N33/54306; Y; Y10; Y10S; Y10S436/00; Y10S436/804; Y10S436/82; Y10S436/822
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
63 words
In an immunoassay method for determining an antigen or an antibody from a test sample and bound to a solid support, the improvement comprising reacting the antigen or antibody bound to the solid support with an antibody having a hapten conjugated thereto and then reacting the hapten portion with labeled antihapten antibody, and measuring the labeled antihapten antibody bound to the solid support.
Claim 2
Dependent Claim
63 words
In an immunoassay method for determining an antigen or an antibody from a test sample and bound to a solid support, the improvement comprising reacting the antigen or antibody bound to the solid support with an antibody having a hapten conjugated thereto and then reacting the hapten portion with labeled antihapten antibody, and measuring the labeled antihapten antibody bound to the solid support.
Claim 3
Dependent Claim
67 words
In an immunoassay method for determining hepatitis B surface antigen from a test sample and bound to a solid support, the improvement comprising reacting the hepatitis surface antigen bound to the solid support with an antibody to hepatitis B surface antigen, said antibody having a hapten conjugated thereto, reacting the hapten portion with labeled antihapten antibody, and measuring the labeled antihapten antibody bound to a solid support.
Claim 4
Dependent Claim
67 words
In an immunoassay method for determining hepatitis B surface antigen from a test sample and bound to a solid support, the improvement comprising reacting the hepatitis surface antigen bound to the solid support with an antibody to hepatitis B surface antigen, said antibody having a hapten conjugated thereto, reacting the hapten portion with labeled antihapten antibody, and measuring the labeled antihapten antibody bound to a solid support.
Claim 5
Dependent Claim
66 words
In an immunoassay method for determining hepatitis B antibody from a test sample and bound to a solid support, the improvement comprising reacting the hepatitis B antibody bound to the solid support with an antibody to the hepatitis B antibody, said antibody having a hapten conjugated thereto, reacting the hapten portion with labeled antihapten antibody, and measuring the labeled antihapten antibody bound to the solid support.
Claim 6
Dependent Claim
66 words
In an immunoassay method for determining hepatitis B antibody from a test sample and bound to a solid support, the improvement comprising reacting the hepatitis B antibody bound to the solid support with an antibody to the hepatitis B antibody, said antibody having a hapten conjugated thereto, reacting the hapten portion with labeled antihapten antibody, and measuring the labeled antihapten antibody bound to the solid support.
Claim 7
Dependent Claim
18 words
An immunoassay reagent which is antibody for hepatitis B surface antigen, said antibody having a hapten conjugated thereto.
Claim 8
Dependent Claim
18 words
An immunoassay reagent which is antibody for hepatitis B surface antigen, said antibody having a hapten conjugated thereto.
Claim 9
Dependent Claim
19 words
An immunoassay reagent which is antibody to hepatitis B surface antigen, said antibody having a 2,4-dinitrophenyl moiety conjugated thereto.
Claim 10
Dependent Claim
19 words
An immunoassay reagent which is antibody to hepatitis B surface antigen, said antibody having a 2,4-dinitrophenyl moiety conjugated thereto.
References Cited (Backward Citations)
US4012494A
Cited
US4034072A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-28 | 1984-04-28 | 1984-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-28 | 1988-04-28 | 1988-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-28 | 1992-04-28 | 1992-10-28 | $7700.00 | Window Closed / Lapsed |