US4230627A
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US
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Fluorovitamin D compounds and processes for their preparation
Assignee: Wisconsin Alumni Research Foundation
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Filing: 1979-08-06
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Granted: 1980-10-28
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Expires: 1999-08-06
Abstract
Abstract Fluorine-substituted vitamin D compounds, methods for preparation of such compounds and fluorinated intermediate compounds used in such methods are disclosed. The fluorine-substituted vitamin D compounds are characterized by vitamin D-like activity in stimulating intestinal calcium transport and bone mobilization and in promoting the calcification of rachitic bone.
Inventors
- 👤 Hector F. DeLuca
- 👤 Heinrich K. Schnoes
- 👤 Joseph L. Napoli, Jr.
- 👤 Bruce L. Onisko
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-07 23:28
CPC Classifications
C; C07; C07C; C07C401/00; C07C2602/00; C07C2602/02; C07C2602/14; C07C2602/18; C07C2602/24; Y; Y02; Y02P; Y02P20/00; Y02P20/50; Y02P20/582
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
45 words
Compounds having the formula ##STR6## where Z is lower alkyl, R 2 is fluoro, R 3 , R 4 , and R 5 are each selected from the group consisting of hydrogen, hydroxy, 0-lower-alkyl, 0-acyl, and fluoro, and R 6 is hydrogen or lower alkyl.
Claim 2
Dependent Claim
45 words
Compounds having the formula ##STR6## where Z is lower alkyl, R 2 is fluoro, R 3 , R 4 , and R 5 are each selected from the group consisting of hydrogen, hydroxy, 0-lower-alkyl, 0-acyl, and fluoro, and R 6 is hydrogen or lower alkyl.
Claim 3
Dependent Claim
13 words
The compounds of claim 1 wherein R 4 is hydrogen, hydroxy or fluoro.
Claim 4
Dependent Claim
13 words
The compounds of claim 2 wherein R 3 is hydrogen, hydroxy, or fluoro.
Claim 5
Dependent Claim
13 words
The compounds of claim 3 wherein R 5 and R 6 are hydrogen.
Claim 6
Dependent Claim
23 words
The compounds of claim 3 wherein R 5 is hydrogen and R 6 is methyl, having the side chain stereochemical configuration of ergosterol.
References Cited (Backward Citations)
US4069321A
Cited
US4119647A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-10-28 | 1984-04-28 | 1984-10-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-10-28 | 1988-04-28 | 1988-10-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-10-28 | 1992-04-28 | 1992-10-28 | $7700.00 | Window Closed / Lapsed |