US4119647A
Expired / Lapsed
US
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25-Hydroxycholecalciferol-23,24-3 H and process for the preparation thereof
Assignee: Hoffmann La Roche Inc
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Filing: 1977-04-11
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Granted: 1978-10-10
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Expires: 1997-04-11
Abstract
Abstract 25-Hydroxycholecalciferol-23,24- 3 H and process for the preparation thereof are disclosed. 25-Hydroxycholecalciferol-23,24- 3 H is useful in radioimmunoassay for the detection of 25-hydroxycholecalciferol, a physiologically important metabolite of cholecalciferol (vitamin D 3 ).
Inventors
- 👤 Arnold Alvin Liebman
- 👤 Richard Robert Muccino
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-06 17:20
CPC Classifications
C; C07; C07J; C07J9/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
159 words
A process for the preparation of a compound of the formula ##STR11## wherein R and R 1 are each independently lower alkanoyl which comprises (a) contacting a compound of the formula ##STR12## wherein R 2 is hydroxy, lower alkoxy, phenyl lower alkoxy, lower alkanoyloxy or benzoyloxy and Z is hydroxy or a group of the formula ##STR13## wherein R 3 is hydrogen or lower alkyl, R 4 and R 5 are each independently lower alkyl and R 4 and R 5 taken together are lower alkylene of from 3 to 8 carbon atoms with a lower alkanoic acid of the formula R.sub.1 OH wherein R 1 is lower alkanoyl to afford a compound of the formula ##STR14## wherein R 1 is as above (b) contacting the compound obtained in step (a) with a lower alkanoic acid anhydride of the formula (R).sub.2 O wherein R is as above in the presence of an acid acceptor and (c) recovering the product.
Claim 2
Dependent Claim
159 words
A process for the preparation of a compound of the formula ##STR11## wherein R and R 1 are each independently lower alkanoyl which comprises (a) contacting a compound of the formula ##STR12## wherein R 2 is hydroxy, lower alkoxy, phenyl lower alkoxy, lower alkanoyloxy or benzoyloxy and Z is hydroxy or a group of the formula ##STR13## wherein R 3 is hydrogen or lower alkyl, R 4 and R 5 are each independently lower alkyl and R 4 and R 5 taken together are lower alkylene of from 3 to 8 carbon atoms with a lower alkanoic acid of the formula R.sub.1 OH wherein R 1 is lower alkanoyl to afford a compound of the formula ##STR14## wherein R 1 is as above (b) contacting the compound obtained in step (a) with a lower alkanoic acid anhydride of the formula (R).sub.2 O wherein R is as above in the presence of an acid acceptor and (c) recovering the product.
Claim 3
Dependent Claim
35 words
The process of claim 1 wherein R and R 1 are the same lower alkanoyl, R 2 is lower alkoxy, R 3 is hydrogen and R 4 and R 5 taken together are lower alkylene.
Claim 4
Dependent Claim
26 words
The process of claim 2 wherein R and R 1 are acetyl, R 2 is alkoxy and R 4 and R 5 taken together are n-butylene.
Claim 5
Dependent Claim
12 words
The process of claim 1 wherein the alkanoic acid is acetic acid.
Claim 6
Dependent Claim
13 words
The process of claim 1 wherein the alkanoic acid anhydride is acetic anhydride.
Claim 7
Dependent Claim
13 words
The process of claim 1 wherein the acid acceptor is a tertiary amine.
Claim 8
Dependent Claim
11 words
The process of claim 6 wherein the tertiary amine is pyridine.
References Cited (Backward Citations)
US3833622A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-10-09 | 1982-04-10 | 1982-10-10 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-10-09 | 1986-04-10 | 1986-10-10 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-10-09 | 1990-04-10 | 1990-10-10 | $7700.00 | Window Closed / Lapsed |