Novel sulfam(na)phthaleins

Claim 1

A compound of the formula ##STR27## wherein R 1 and R 2 each are selected from hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, chloro and fluoro; R 3 is hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms or hydroxy; R 2 and R 3 taken together represent the carbon atoms necessary to complete a fused benzene ring; R 4 and R 6 each are selected from hydrogen, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, chloro and fluoro; R 7 is hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms; R 6 and R 7 taken together represent the carbon atoms necessary to complete a fused benzene ring provided R 2 and R 3 are taken separately when R 6 and R 7 are taken together; R 5 is selected from hydrogen, hydroxy, alkyl having 1 to 4 carbon atoms, alkoxy having 1 to 4 carbon atoms, --N,N-(dialkyl)amino wherein each alkyl contains 1 to 4 carbon atoms, --N,N-(w-R 8 alkyl) 2 amino wherein R 8 is hydroxy or halo and said alkyl contains 1 to 4 carbon atoms, --NHCOCH 3 , piperidino, pyrrolidino, N-methylpiperazino, morpholino, thiomorpholino or tetrahydro-2H,4H-1,3,6-dioxazocino; R 4 , R 5 and R 6 taken together represent the atoms necessary to complete a fused quinolizidine ring; X represents the atoms necessary to complete 2,3-dihydrobenzisothiazole-1,1-dioxide or 2,3-dihydronaphtho-1,2-thiazine-1,1-dioxide; and R 9 is selected from lower alkyl having 1 to 4 carbon atoms and phenyl, unsubstituted or substituted with at least one electron-withdrawing group having a positive sigma value as defined by Hammett's Equation selected from the group consisting of fluoro, chloro, bromo, cyano, --SO 2 CH 3 , ##STR28## and --COCH 3 .