US4225610A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Immunoactivators derived from amino thiazoles
Assignee: Pierre Fabre SA
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Filing: 1978-10-19
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Granted: 1980-09-30
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Expires: 1998-10-19
Abstract
Abstract The present invention concerns new derivatives of 4-phenyl 2-amino thiazole of the formula <IMAGE> in which X represents a hydrogen atom, a halogen, a lower alkyl or an alkoxy, R is a hydrogen, a haloalkoxy, a substituted or unsubstituted aryl, a pyridyl, an aryloxy or a carboxy alkyl, having immunomodulating properties, useful in the treatment of rheumatoid arthritis and other ailments requiring immunotherapy.
Inventors
- 👤 Jean-Pierre Tarayre
- 👤 Henri Cousse
- 👤 Gilbert Mouzin
- 👤 Henri Lauressergues
- 👤 Silvano Casadio
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 22:14
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/38; C07D277/40; A; A61; A61P; A61P29/00; A61P35/00; A61P37/00; A61P37/02; A61P37/04; C07D277/44; C07D277/46; C07D277/48
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
45 words
4-phenyl-2-amino thiazoles having the formula: ##STR19## in which: X represents a hydrogen atom, a halogen, a lower alkyl, or an alkoxy, R represents --O--C--(Cl) 3 ; --O--CH 2 --C(Cl) 3 ; --O--CH 2 --CH 2 --CH 2 --Br; --O--CH 2 --CHBr 2 ; or carboxyalkyl.
Claim 2
Dependent Claim
45 words
4-phenyl-2-amino thiazoles having the formula: ##STR19## in which: X represents a hydrogen atom, a halogen, a lower alkyl, or an alkoxy, R represents --O--C--(Cl) 3 ; --O--CH 2 --C(Cl) 3 ; --O--CH 2 --CH 2 --CH 2 --Br; --O--CH 2 --CHBr 2 ; or carboxyalkyl.
Claim 3
Dependent Claim
26 words
A compound of claim 1, selected from: 4-phenyl 2-(2'-2'-2'-trichlorethoxy carboxamido) thiazole, 4-parachlorophenyl 2-(2'-2'-2'-trichlorethoxy carboxamido) thiazole, 4-paramethyl phenyl 2-(2'-2'-2'-trichlorethoxy carboxamido) thiazole, and 4-paramethoxy phenyl 2-(2'-2'-2'-trichlorethoxy carboxamido) thiazole.
Claim 4
Dependent Claim
25 words
A pharmaceutical composition, useful in immunotherapy, containing an effective immune response elevating amount of a compound of claim 1, together with a pharmaceutically acceptable carrier.
Claim 5
Dependent Claim
17 words
The pharmaceutical composition as claimed in claim 3, wherein said compound is a compound of claim 2.
Claim 6
Dependent Claim
37 words
A method for the treatment of a patient suffering from a depressed immune response condition, comprising the step of administering to said patient a compound of claim 1 in an amount effective for alleviation of said condition.
Claim 7
Dependent Claim
15 words
The method of claim 5, wherein the compound administered is a compound of claim 2.
Claim 8
Dependent Claim
15 words
The method of claim 6, wherein the compound is administered in an immune-response elevating amount.
Claim 9
Dependent Claim
15 words
Compound of claim 1 wherein R is a higher alkyl group of 8-28 carbon atoms.
Claim 10
Dependent Claim
12 words
The method of claim 5, wherein the condition treated is rheumatoid arthritis.
Claim 11
Dependent Claim
24 words
The method of claim 9, wherein the compound administered is a compound of claim 2 in an amount effective for alleviation of said condition.
Claim 12
Dependent Claim
11 words
A compound of claim 1 which is 4-phenyl 2-(2'-2'-2'-trichlorethoxy carboxamido) thiazole.
Claim 13
Dependent Claim
14 words
A pharmaceutical composition of claim 3, wherein the compound is 4-phenyl 2-(2'-2'-2'-trichlorethoxy carboxamido) thiazole.
Claim 14
Dependent Claim
13 words
The method of claim 5, wherein the compound is 4-phenyl 2-(2'-2'-2'-trichlorethoxy carboxamido) thiazole.
References Cited (Backward Citations)
US4134984A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-30 | 1984-03-31 | 1984-09-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-30 | 1988-03-31 | 1988-09-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-30 | 1992-03-31 | 1992-09-30 | $7700.00 | Window Closed / Lapsed |