US4134984A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Thiazole compositions
Assignee: John Wyeth and Brother Ltd
•
Filing: 1976-11-10
•
Granted: 1979-01-16
•
Expires: 1996-11-10
Abstract
Abstract The invention relates to the use of thiazoles in the treatment of ulcers and/or hypersecretion in mammals. The invention also provides in a preferred aspect a pharmaceutical composition for use in the treatment of ulcers or hypersecretion comprising a compound of formula I ##STR1## where R 1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms (which may be substituted by chlorine), or cyclopropyl, R 3 is hydrogen or COR 4 where R 4 is as defined for R and R and R 4 may be the same or different and a pharmaceutically acceptable carrier.
Inventors
- 👤 Roger Crossley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 03:48
CPC Classifications
C; C07; C07D; C07D277/00; C07D277/02; C07D277/20; C07D277/32; C07D277/38; C07D277/44; C07D277/46
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
87 words
A pharmaceutical composition in oral dosage form for use in the treatment of ulcers or hypersecretion comprising a therapeutically effective amount of a compound of formula I ##STR12## where R 1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms, which may be substituted by chlorine, or cyclopropyl, R 3 is hydrogen or COR 4 where R 4 is as defined for R and R and R 4 may be the same or different and a pharmaceutically acceptable carrier.
Claim 2
Dependent Claim
87 words
A pharmaceutical composition in oral dosage form for use in the treatment of ulcers or hypersecretion comprising a therapeutically effective amount of a compound of formula I ##STR12## where R 1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms, which may be substituted by chlorine, or cyclopropyl, R 3 is hydrogen or COR 4 where R 4 is as defined for R and R and R 4 may be the same or different and a pharmaceutically acceptable carrier.
Claim 3
Dependent Claim
12 words
A pharmaceutical composition as claimed in claim 1, in unit dosage form.
Claim 4
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 2 in the form of a tablet or capsule.
Claim 5
Dependent Claim
23 words
A pharmaceutical composition as claimed in claim 2, wherein the amount of compound I is from 50 to 250 mg per unit dose.
Claim 6
Dependent Claim
82 words
A pharmaceutical composition for use in the treatment of ulcers or hypersecretion comprising an antacid ingredient and a therapeutically effective amount of a compound of formula I ##STR13## where R 1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms, which may be substituted by chlorine, or cyclopropyl, R 3 is hydrogen or COR 4 where R 4 is as defined for R and R and R 4 may be the same or different.
Claim 7
Dependent Claim
82 words
A pharmaceutical composition for use in the treatment of ulcers or hypersecretion comprising an antacid ingredient and a therapeutically effective amount of a compound of formula I ##STR13## where R 1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms, which may be substituted by chlorine, or cyclopropyl, R 3 is hydrogen or COR 4 where R 4 is as defined for R and R and R 4 may be the same or different.
Claim 8
Dependent Claim
15 words
A pharmaceutical composition as claimed in claim 1, wherein R 1 is hydrogen or methyl.
Claim 9
Dependent Claim
14 words
A pharmaceutical composition as claimed in claim 1, wherein R is hydrogen or methyl.
Claim 10
Dependent Claim
13 words
A pharmaceutical composition as claimed in claim 1 wherein R 3 is hydrogen.
Claim 11
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 8, wherein the compound of formula I is 4-acetamidothiazole.
Claim 12
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 8, wherein the compound of formula I is 4-acetamido-5-methylthiazole.
Claim 13
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 8, wherein the compound of formula I is 4-formamidothiazole.
Claim 14
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 8, wherein the compound of formula I is 4-propionamidothiazole.
Claim 15
Dependent Claim
19 words
A pharmaceutical composition as claimed in claim 1, wherein R 3 is COR 4 and R 4 is methyl.
Claim 16
Dependent Claim
16 words
A pharmaceutical composition as claimed in claim 13, wherein the compound of formula I is 4-diacetamidothiazole.
Claim 17
Independent Claim
83 words
A method of treating ulcers or hypersecretion in an afflicted mammal which method comprises orally administering to said mammal an effective amount of a compound of formula I ##STR14## where R 1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms, which may be substituted by chlorine, or cyclopropyl, R 3 is hydrogen or COR 4 where R 4 is as defined for R and R and R 4 may be the same or different.
Claim 18
Independent Claim
83 words
A method of treating ulcers or hypersecretion in an afflicted mammal which method comprises orally administering to said mammal an effective amount of a compound of formula I ##STR14## where R 1 is hydrogen, alkyl of 1-6 carbon atoms, or phenyl, R is hydrogen, n-alkyl of 1-4 carbon atoms, which may be substituted by chlorine, or cyclopropyl, R 3 is hydrogen or COR 4 where R 4 is as defined for R and R and R 4 may be the same or different.
Claim 19
Dependent Claim
25 words
A method as claimed in claim 15 wherein the compound of formula I is administered in a dose range of from 3 to 100 mg/kg.
Claim 20
Dependent Claim
16 words
A method as claimed in claim 16, wherein the compound is 4-acetamidothiazole, 4-formamidothiazole, 4-acetamido-5-methylthiazole or 4-diacetamidothiazole.
References Cited (Backward Citations)
US3244723A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-15 | 1982-07-17 | 1983-01-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-15 | 1986-07-17 | 1987-01-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-15 | 1990-07-17 | 1991-01-16 | $7700.00 | Window Closed / Lapsed |