Patent US4225472A successfully refreshed from Google Patents.
US4225472A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Truncated somatostatin analogs
Assignee: Wyeth LLC
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Filing: 1979-05-29
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Granted: 1980-09-30
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Expires: 1999-05-29
Abstract
Abstract Polypeptides of the formula: ##STR1## in which X 1 is hydrogen, des-amino, Ala-Gly- or Ala-D-Ala; X 2 is Trp, Leu, Met or p-Cl-Phe; and X 3 is D-Trp or 5- or 6-fluoro-D-Trp; the linear precursor intermediates thereof or pharmaceutically acceptable salts thereof are selective inhibitors of growth hormone and glucagon release without materially altering blood serum levels of insulin.
Inventors
- 👤 Dimitrios Sarantakis
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-05 11:43
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/575; C07K14/655; C07K14/6555; A; A61; A61P; A61P3/00; A61P3/08; A61K; A61K38/00; Y; Y10; Y10S; Y10S930/00; Y10S930/01; Y10S930/16; Y10S930/28
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
46 words
A compound of the formula ##STR5## in which X 1 is hydrogen, des-amino- Ala-Gly- or Ala-D-Ala-; X 3 is D-Trp or 5- or 6- fluoro-D-Trp; and the A groups are hydrogen or a direct bond between the two sulfur atoms; or a pharmaceutically acceptable salt thereof.
Claim 2
Dependent Claim
46 words
A compound of the formula ##STR5## in which X 1 is hydrogen, des-amino- Ala-Gly- or Ala-D-Ala-; X 3 is D-Trp or 5- or 6- fluoro-D-Trp; and the A groups are hydrogen or a direct bond between the two sulfur atoms; or a pharmaceutically acceptable salt thereof.
Claim 3
Dependent Claim
14 words
A compound of claim 1 which is ##STR6## or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
8 words
A compound of claim 1 which is ##STR7##
Claim 5
Dependent Claim
12 words
A compound of claim 1 which is tert-Butyloxycarbonyl-S-p-methoxybenzyl-L-cysteinyl-L-phenylalanyl-L-tryptophyl-D-tryptophyl-N-.sup.ε -2-chlorobenzyloxycarbonyl-L-lysyl-O-benzyl-L-threonyl-L-phenylalanyl-S-p-methoxybenzyl-D-cysteine hydroxymethyl polystyrene ester.
Claim 6
Dependent Claim
63 words
A compound of claim 1 which is ##STR8## in which R is hydrogen or an alpha amino protecting group; R 1 and R 2 are hydrogen or a sulfhydryl protecting group; R 3 is hydrogen or a N.sup.ε protecting group of Lys; R 4 is hydrogen or a hydroxyl protecting group of Thr; and R 5 is hydrogen or --CH 2 (polystyrene resin).
References Cited (Backward Citations)
US4105603A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-30 | 1984-03-31 | 1984-09-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-30 | 1988-03-31 | 1988-09-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-30 | 1992-03-31 | 1992-09-30 | $7700.00 | Window Closed / Lapsed |