Patent US4224336A successfully refreshed from Google Patents.
US4224336A
Expired / Lapsed
US
⏱️ 0.0 years remaining
3-(2-Aminoethylthio)-6-amido-7-oxo-1-azabicyclo[3.2.0]-hept-2-ene-2-carboxylic acid
Assignee: Merck and Co Inc
•
Filing: 1979-04-17
•
Granted: 1980-09-23
•
Expires: 1999-04-17
Abstract
Abstract Disclosed are 3-(2-aminoethylthio)-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids having the structure: ##STR1## wherein R 1 is hydrogen or acyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
Inventors
- 👤 Burton G. Christensen
- 👤 Ravindra N. Guthikonda
- 👤 David B. R. Johnston
- 👤 Susan M. Schmitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-10 02:24
CPC Classifications
C; C07; C07D; C07D477/00; C07D477/10; C07C; C07C205/00; C07C205/39; C07C205/42; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07D205/085; C07D477/24; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/10
Claims Analysis
Total Claims: 3
Claim 1
Independent Claim
60 words
A compound having the structural formula: ##STR76## wherein R is hydrogen, the pharmaceutically acceptable salts or cations or lower alkyl having 1-4 carbon atoms; lower alkenyl having 1-4 carbon atoms; benzyl, p-nitrobenzyl, pivaloyloxymethyl, 3-phthalidyl or phenacyl; and R 1 is hydrogen, or phenylacetyl, phenoxyacetyl, 3-bromophenylacetyl, p-aminomethylphenylacetyl, 4-carboxymethylphenylacetyl, 4-carboxyamidomethylphenylacetyl, phenylthioacetyl, α-fluorophenylacetyl, D-phenylglycyl, 3-hydroxy-D-phenylglycyl, phenylmalonly, 3-chlorophenylmalonyl, α-phosphonophenylacetyl, α-sulfaminophenylacetyl, α-hydroxyphenylacetyl, α-tetrazolylphenylacetyl and α-sulfophenylacetyl.
Claim 2
Dependent Claim
60 words
A compound having the structural formula: ##STR76## wherein R is hydrogen, the pharmaceutically acceptable salts or cations or lower alkyl having 1-4 carbon atoms; lower alkenyl having 1-4 carbon atoms; benzyl, p-nitrobenzyl, pivaloyloxymethyl, 3-phthalidyl or phenacyl; and R 1 is hydrogen, or phenylacetyl, phenoxyacetyl, 3-bromophenylacetyl, p-aminomethylphenylacetyl, 4-carboxymethylphenylacetyl, 4-carboxyamidomethylphenylacetyl, phenylthioacetyl, α-fluorophenylacetyl, D-phenylglycyl, 3-hydroxy-D-phenylglycyl, phenylmalonly, 3-chlorophenylmalonyl, α-phosphonophenylacetyl, α-sulfaminophenylacetyl, α-hydroxyphenylacetyl, α-tetrazolylphenylacetyl and α-sulfophenylacetyl.
Claim 3
Dependent Claim
21 words
An antibiotic pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 and a pharmaceutical carrier therefor.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-23 | 1984-03-24 | 1984-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-23 | 1988-03-24 | 1988-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-23 | 1992-03-24 | 1992-09-23 | $7700.00 | Window Closed / Lapsed |