Patent US4224319A successfully refreshed from Google Patents.
US4224319A
Expired / Lapsed
US
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Antiseptic composition for topical application to the skin
Assignee: Individual
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Filing: 1979-07-31
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Granted: 1980-09-23
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Expires: 1999-07-31
Abstract
Abstract An antiseptic composition, particularly useful against bromidrosis, is prepared by using a disinfecting surface-active amino acid in water having dispersed therein one or several triglycerides of fatty acids of C 12 to C 20 . The composition contains 0.3 to 5% by weight of the above bactericidal and fungicidal surface-active amino acid, a fatty material comprising said triglyceride, water and at least one of the vitamins A and E, and preferably also some sterols. The amino acid has the structure RNH(R 1 NH) n R 2 COOH where R is an aliphatic chain of 8 to 18C, R 1 and R 2 are C 1 to C 3 alkylenes, while n is 0 or 1.0 or 2.0. Preferably the composition further contains a pesticide quaternary ammonium derivative. The composition is very effective agaist bromidrosis, particularly that of the feet, without any irritant action on the skin.
Inventors
- 👤 Ernest Marcadet
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-02 21:03
CPC Classifications
A; A01; A01N; A01N37/00; A01N37/44; A61; A61K; A61K31/00; A61K31/185; A61K31/19; A61K31/195; A61K31/33; A61K31/335; A61K31/35; A61K31/352; A61K31/353; A61K31/355; A61K31/56; A61K47/00; A61K47/06; A61K47/08; A61K47/14; A61K9/00; A61K9/0012; A61K9/0014
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
145 words
An aqueous composition, for prolonged application to the skin without irritation and useful against bromidrosis, which comprises an aqueous solution of a surface-active amino-acid having the structure R--NH (R.sup.1 NH).sub.n --R.sup.2 --COOH where R is an aliphatic chain of 8 to 18 carbon atoms, R 1 and R 2 , identical or different, are C 1 to C 3 alkylenes, while n is 0 to 1, the amount of the amino-acid being of 0.3% to 5% by weight of the composition, and the solution contains dispersed therein 1.5% to 15% by weight of a triglyceride of a fatty acid having 12 to 20 carbon atoms, and at least one of the vitamins A and E at a concentration of 40-12,000 International Units per 100 grams of composition as concerns the vitamin A and 1.0-40 International Units per 100 grams of composition as concerns vitamin E.
Claim 2
Dependent Claim
145 words
An aqueous composition, for prolonged application to the skin without irritation and useful against bromidrosis, which comprises an aqueous solution of a surface-active amino-acid having the structure R--NH (R.sup.1 NH).sub.n --R.sup.2 --COOH where R is an aliphatic chain of 8 to 18 carbon atoms, R 1 and R 2 , identical or different, are C 1 to C 3 alkylenes, while n is 0 to 1, the amount of the amino-acid being of 0.3% to 5% by weight of the composition, and the solution contains dispersed therein 1.5% to 15% by weight of a triglyceride of a fatty acid having 12 to 20 carbon atoms, and at least one of the vitamins A and E at a concentration of 40-12,000 International Units per 100 grams of composition as concerns the vitamin A and 1.0-40 International Units per 100 grams of composition as concerns vitamin E.
Claim 3
Dependent Claim
23 words
The composition according to claim 1, wherein the content of vitamin A is of 1,000 to 5,000 I.U. per 100 grams of composition.
Claim 4
Dependent Claim
22 words
The composition according to claim 1, wherein the content of vitamin E is 1 to 25 I.U. per 100 grams of composition.
Claim 5
Dependent Claim
42 words
The composition according to claim 1, which contains one or more sterol selected from the group consisting of cholesterol, agnosterol, ergosterol, dehydrocholesterol, cholestanol, beta-sitosterol, zymosterol, lathosterol, hydroxycholesterol, dehydro-ergosterol, and ascosterol in an amount of 0.02 to 0.5% by weight of the composition.
Claim 6
Dependent Claim
55 words
The composition according to claim 1, wherein said amino-acid is selected from the group consisting of n-dodecyl-aminoacetic acid, n-tetradecyl-amino-propionic acid, n-hexadecyl-aminoacetic acid, hexadecyl-aminobutyric acid, stearyl-aminoacetic acid, stearyl-aminopropionic acid, oleyl-aminoacetic acid, oleyl-aminopropionic acid, linoleyl-aminoacetic acid, linoleyl-aminobutyric acid, dodecyl-ethylenediamino acetic acid, dodecyl-ethylenediamino-propionic acid, dodecyl-diethylenetriamino-propionic acid, oleyl-ethylene diamino-acetic acid, stearyl-ethylene diamino-propionic acid, linoleyl-ethylene-diamino butyric acid, and linoleyl-diethylene-triamino-propionic acid.
Claim 7
Dependent Claim
34 words
The composition according to claim 1, where said amino-acid consists of a mixture of at least two amino-acids each having different aliphatic chains R in the range of C 8 to C 18 .
Claim 8
Dependent Claim
28 words
The composition according to claim 1, wherein the said triglyceride is selected from the group consisting of olive oil, palm oil, hazel nut oil, and sweet almond oil.
Claim 9
Dependent Claim
89 words
The composition according to claim 1, which contains a quarternary ammonium pesticide of the formula ##STR6## where R is a alkyl having 12 to 18 carbon atoms, R 1 and R 2 are lower alkyls, R 3 is a radical selected from the group consisting of lower alkyls and benzyl, and X is an anion selected from the group consisting of chloride, bromide, acetate, propionate, tartarate, phosphate and saccharinate, the amount of the ammonium pesticide being in the range of 1/200 to 1/4 of the weight of the amino-acid.
Claim 10
Dependent Claim
17 words
The composition according to claim 1, the pH of which is in the range 5.5 to 8.
Claim 11
Dependent Claim
22 words
The composition according to claim 9, which has a pH value adjusted to a value in the range of 6 to 7.5.
Claim 12
Dependent Claim
40 words
The composition according to claim 1, which contains a sterol in an amount of 0.02 to 0.5% by weight, the sterol being selected from the group consisting of cholesterol, agnosterol, ergosterol, dehydrocholesterol, cholestanol, beta-sitosterol, zymosterol, lathosterol, hydroxycholesterol, dehydro-ergosterol, and ascosterol.
Claim 13
Dependent Claim
45 words
The composition according to claim 1, wherein the triglyceride is provided by the addition of a natural fatty substance including glycerine and a fatty acid selected from the group consisting of lauric, myristic, palmitic, stearic, arachidic, palmitolic, oleic, eleostearic, linoleic, linolenic, arachidonic, and ricinoleic acid.
Claim 14
Dependent Claim
32 words
The composition according to claim 1, wherein said amino-acid consists of amino-acids having different aliphatic chains R chosen from the group consisting of octyl, capryl, lauryl, myristyl, cetyl, stearyl, oleyl and linoleyl.
Claim 15
Dependent Claim
146 words
A disinfectant composition which comprises an aqueous solution having 0.6 to 2.5% by weight of alkyl-diethylene-triamino-acid acid, the alkyls of which contain C 8 to C 18 with about 80% of them containing C 12 and C 14 the solution having dispersed therein 2 to 10% by weight of sweet almond oil and containing 1,000 to 5,000 I.U. of vitamin A, 1 to 25 I.U. of vitamin E and 50 to 50,000 I.U. of vitamin D per 100 grams of composition, and having also dispersed therein an amount of lanoline capable of providing 0.02 to 0.5% by weight of sterols selected from the group consisting of cholesterol, agnosteol, ergosterol, dehydrocholesterol, cholestanol, beta-sitosterol, and ascosterol as well as 0.015 to 1.1% by weight of an alkanol having 8, 12, or 16 carbon atoms, the pH of the composition being adjusted to a value of 6.5 to 7.2.
Claim 16
Dependent Claim
146 words
A disinfectant composition which comprises an aqueous solution having 0.6 to 2.5% by weight of alkyl-diethylene-triamino-acid acid, the alkyls of which contain C 8 to C 18 with about 80% of them containing C 12 and C 14 the solution having dispersed therein 2 to 10% by weight of sweet almond oil and containing 1,000 to 5,000 I.U. of vitamin A, 1 to 25 I.U. of vitamin E and 50 to 50,000 I.U. of vitamin D per 100 grams of composition, and having also dispersed therein an amount of lanoline capable of providing 0.02 to 0.5% by weight of sterols selected from the group consisting of cholesterol, agnosteol, ergosterol, dehydrocholesterol, cholestanol, beta-sitosterol, and ascosterol as well as 0.015 to 1.1% by weight of an alkanol having 8, 12, or 16 carbon atoms, the pH of the composition being adjusted to a value of 6.5 to 7.2.
Claim 17
Dependent Claim
67 words
An aqueous disinfectant composition, suitable for prolonged application to the skin without irritation and useful against bromidrosis, which comprises an aqueous solution of: (a) 1 wt. % of dodicin, (b) a vitamin component chosen from the group consisting of: 400 I.U. (per 100 grams of composition) of Vitamin A, and 1 I.U. (per 100 grams of composition) of Vitamin E, and (c) 3 wt. % oleic triglyceride.
Claim 18
Dependent Claim
67 words
An aqueous disinfectant composition, suitable for prolonged application to the skin without irritation and useful against bromidrosis, which comprises an aqueous solution of: (a) 1 wt. % of dodicin, (b) a vitamin component chosen from the group consisting of: 400 I.U. (per 100 grams of composition) of Vitamin A, and 1 I.U. (per 100 grams of composition) of Vitamin E, and (c) 3 wt. % oleic triglyceride.
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| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
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| 3.5 Years (Year 4) | 1983-09-23 | 1984-03-24 | 1984-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-23 | 1988-03-24 | 1988-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-23 | 1992-03-24 | 1992-09-23 | $7700.00 | Window Closed / Lapsed |