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US4221804A
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Mercaptoacyldihydropyrazole carboxylic acid derivatives
Assignee: Individual
•
Filing: 1979-09-27
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Granted: 1980-09-09
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Expires: 1999-09-27
Abstract
Abstract Hypertension can be treated using compounds having the formula ##STR1## or a basic salt thereof, wherein R 1 is hydrogen, alkyl, aryl, arylalkyl or ##STR2## wherein R 5 is alkyl or aryl; R 2 is hydrogen or alkyl; R 3 is aryl; R 4 is hydrogen, alkyl or arylalkyl and n is 0, 1 or 2.
Inventors
- 👤 George C. Rovnyak
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 02:54
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/06; C07C; C07C59/00; C07C59/40; C07C59/76; C07C59/88; C07C59/90
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
89 words
A compound having the formula ##STR17## or a non-toxic, physiologically acceptable basic salt thereof, where R 2 is hydrogen or alkyl; R 3 is aryl; R 4 is hydrogen, alkyl or arylalkyl; R 5 is alkyl or aryl; and n is 0, 1 or 2; wherein the term "aryl" refers to phenyl or phenyl substituted with one, two or three halogen, alkyl, alkoxy, hydroxy, ##STR18## nitro, amino, alkylamino, dialkylamino, trifluoromethyl, cyano or carboxyl groups, and the terms "alkyl" and "alkoxy" refer to groups having 1 to 8 carbon atoms.
Claim 2
Dependent Claim
89 words
A compound having the formula ##STR17## or a non-toxic, physiologically acceptable basic salt thereof, where R 2 is hydrogen or alkyl; R 3 is aryl; R 4 is hydrogen, alkyl or arylalkyl; R 5 is alkyl or aryl; and n is 0, 1 or 2; wherein the term "aryl" refers to phenyl or phenyl substituted with one, two or three halogen, alkyl, alkoxy, hydroxy, ##STR18## nitro, amino, alkylamino, dialkylamino, trifluoromethyl, cyano or carboxyl groups, and the terms "alkyl" and "alkoxy" refer to groups having 1 to 8 carbon atoms.
Claim 3
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 2 is hydrogen.
Claim 4
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 2 is methyl.
Claim 5
Dependent Claim
12 words
A compound is accordance with claim 1 wherein R 4 is hydrogen.
Claim 6
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 4 is alkyl.
Claim 7
Dependent Claim
12 words
A compound in accordance with claim 1 wherein R 4 is arylalkyl.
Claim 8
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is O.
Claim 9
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 1.
Claim 10
Dependent Claim
11 words
A compound in accordance with claim 1 wherein n is 2.
Claim 11
Dependent Claim
9 words
The compound in accordance with claim 1 DL-4,5-dihydro-1-[3-(acetylthio)-1-oxopropyl]-3-phenyl-1H-pyrazole-5-carboxylic acid.
Claim 12
Dependent Claim
9 words
The compound in accordance with claim 1, DL-3-(4-chlorophenyl)-4,5-dihydro-1-[3-(acetylthio)-1-oxopropyl]-1H-pyrazole-5-carboxylic acid.
Claim 13
Dependent Claim
9 words
The compound in accordance with claim 1, D,L-3-(4-methoxyphenyl)-4,5-dihydro-1-[3-(acetylthio)-1-oxopropyl]-1H-pyrazole-5-carboxylic acid.
Claim 14
Dependent Claim
9 words
The compound in accordance with claim 1, D,L-3-(4-fluorophenyl)-4,5-dihydro-1-[3-(acetylthio)-1-oxopropyl]-1H-pyrazole-5-carboxylic acid.
Claim 15
Independent Claim
109 words
A method for reducing blood pressure in mammals which comprises administering to a mammal in need thereof, an effective amount of a compound having the formula ##STR19## or a non-toxic, physiologically acceptable basic salt thereof, wherein R 2 is hydrogen or alkyl; R 3 is aryl; R 4 is hydrogen, alkyl or arylalkyl; R 5 is alkyl or aryl; and n is 0, 1 or 2; wherein the term "aryl" refers to phenyl or phenyl substituted with one, two three halogen, alkyl, alkoxy, hydroxy, ##STR20## nitro, amino, alkylamino, dialkylamino, trifluoromethyl, cyano or carboxyl groups, and the terms "alkyl" and "alkoxy" refer to groups having 1 to 8 carbon atoms.
Claim 16
Independent Claim
109 words
A method for reducing blood pressure in mammals which comprises administering to a mammal in need thereof, an effective amount of a compound having the formula ##STR19## or a non-toxic, physiologically acceptable basic salt thereof, wherein R 2 is hydrogen or alkyl; R 3 is aryl; R 4 is hydrogen, alkyl or arylalkyl; R 5 is alkyl or aryl; and n is 0, 1 or 2; wherein the term "aryl" refers to phenyl or phenyl substituted with one, two three halogen, alkyl, alkoxy, hydroxy, ##STR20## nitro, amino, alkylamino, dialkylamino, trifluoromethyl, cyano or carboxyl groups, and the terms "alkyl" and "alkoxy" refer to groups having 1 to 8 carbon atoms.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-09 | 1984-03-10 | 1984-09-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-09 | 1988-03-10 | 1988-09-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-09 | 1992-03-10 | 1992-09-09 | $7700.00 | Window Closed / Lapsed |