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US4220649A
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US
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1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives
Assignee: Astellas Pharma Inc
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Filing: 1979-01-31
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Granted: 1980-09-02
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Expires: 1999-01-31
Abstract
Abstract 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives shown by the formula ##STR1## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group or an aralkyl group, and the therapeutically non-toxic salts thereof. These compounds possess a vasodilative activity and an antihypertensive activity.
Inventors
- 👤 Tadao Kojima
- 👤 Toichi Takenaka
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-25 22:56
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/12; A; A61; A61P; A61P9/00; A61P9/12
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
35 words
1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives represented by the formula ##STR25## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group, or benzyl phenylethyl, and the therapeutically non-toxic salts thereof.
Claim 2
Dependent Claim
35 words
1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives represented by the formula ##STR25## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group, or benzyl phenylethyl, and the therapeutically non-toxic salts thereof.
Claim 3
Dependent Claim
13 words
2,6-Dimethyl-4-(3'-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-(1-benzylpyrrolidin-3-yl)ester 5-methyl ester or the hydrochloride thereof as claimed in claim 1.
Claim 4
Dependent Claim
26 words
A compound as claimed in claim 1, wherein said salts are selected from the group consisting of the hydrochloride, sulfate, phosphate, acetate, fumarate, maleate, and tartrate.
Claim 5
Dependent Claim
53 words
An antihypertensive composition comprising a mixture of a 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivative represented by the formula ##STR26## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group, benzyl or phenylethyl, or a therapeutically non-toxic salt thereof as the active ingredient, and a therapeutically acceptable carrier therefor.
Claim 6
Dependent Claim
53 words
An antihypertensive composition comprising a mixture of a 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivative represented by the formula ##STR26## wherein R represents a lower alkyl group and R' represents a hydrogen atom, a lower alkyl group, benzyl or phenylethyl, or a therapeutically non-toxic salt thereof as the active ingredient, and a therapeutically acceptable carrier therefor.
Claim 7
Dependent Claim
20 words
A composition as claimed in claim 4, comprising 2,6-Dimethyl-4-(3'nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid-3-(1-benzylpyrrolidin-3-yl)ester 5-methyl ester or the hydrochloride thereof as the active ingredient.
Claim 8
Dependent Claim
19 words
A method of treating hypertension comprising administering an antihypertensive effective amount of the composition of claim 4 or 5.
Claim 9
Dependent Claim
34 words
A method as claimed in claim 6, comprising administering by intravenous injection an amount of said composition to provide from 0.1 to 1 mg of said active ingredient per dose in an aqueous solution.
Claim 10
Dependent Claim
28 words
A method as claimed in claim 6, comprising orally administering an amount of said composition to provide from 5 to 20 mg of said active ingredient per dose.
References Cited (Backward Citations)
US3996234A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-02 | 1984-03-03 | 1984-09-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-02 | 1988-03-03 | 1988-09-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-02 | 1992-03-03 | 1992-09-02 | $7700.00 | Window Closed / Lapsed |