US4219426A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Dialysis device
Assignee: Biomerieux BV
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Filing: 1977-03-14
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Granted: 1980-08-26
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Expires: 1997-03-14
Abstract
Abstract The invention relates to a separating device, more particularly for hemodialysis, comprising a housing accommodating at least one bundle of a large number of tubular, selectively permeable membranes connected in parallel whose transverse dimensions are very small relative to their longitudinal dimensions. The ends of the membranes rest on supporting members in the housing. The membranes may be the walls of hollow fibers which divide the internal part of the separating device into a first medium space provided by the inside of the membranes and a second medium space inside the housing but outside the membranes. The medium spaces are each provided with an inlet and an outlet for respectively the supply and the discharge of a first and a second medium, which media can enter into exchange through the walls of the membranes.
Inventors
- 👤 Hendrikus J. Spekle
- 👤 Johannes P. Brants
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 03:30
CPC Classifications
B; B01; B01D; B01D63/00; B01D63/02; B01D63/021; B01D63/022; B01D63/0222; B29; B29C; B29C39/00; B29C39/02; B29C39/04; B29C39/08; B29C70/00; B29C70/68; B29C70/84; B29C70/845; B29L; B29L2031/00; B29L2031/14
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
302 words
A dialysis device comprising an elongated tubular member, a ring with a diameter larger than the diameter of the tubular member and disposed in concentric overlapping arrangement about each end portion of the tubular member secured thereto in radially outwardly spaced relationship to form an annular space therebetween, each end portion of said tubular member having circumferentially spaced crenels, a bundle of hollow regenerated cellulose fibers disposed in the tubular member with ends disposed adjacent the ends of the tubular member, longitudinally-spaced annular soft rubber-like rings substantially impassable to a liquid passing through said device and disposed in the tubular member about the bundle, a solid elastomeric composition filling voids about the ends of the fibers and sealing the ends of the tubular member against longitudinal liquid flow therefrom, said composition also sealing the open ends of said annular space but not sealing all of the spaces between crenels whereby liquid can flow from an annular space into the space about the fibers in the tubular member at one end of the tubular member and out of the space in the tubular member into the annular space at the opposite end of the tubular member, means for introducing dialysis fluid into one annular space, means for removing dialysis fluid from the other annular space to create flow of dialysis fluid in the tubular member about the fibers, convex disks having an annular prong near their peripheral edges impressed in said elastomeric composition radially outwardly from the fibers sealing a space between the disk and the end of the fiber bundle, said disks being end closure members for the tubular member, means for the flow of blood into one of the last said spaces and into the fibers, and means for the flow of blood from the second of the last said spaces.
Claim 2
Dependent Claim
302 words
A dialysis device comprising an elongated tubular member, a ring with a diameter larger than the diameter of the tubular member and disposed in concentric overlapping arrangement about each end portion of the tubular member secured thereto in radially outwardly spaced relationship to form an annular space therebetween, each end portion of said tubular member having circumferentially spaced crenels, a bundle of hollow regenerated cellulose fibers disposed in the tubular member with ends disposed adjacent the ends of the tubular member, longitudinally-spaced annular soft rubber-like rings substantially impassable to a liquid passing through said device and disposed in the tubular member about the bundle, a solid elastomeric composition filling voids about the ends of the fibers and sealing the ends of the tubular member against longitudinal liquid flow therefrom, said composition also sealing the open ends of said annular space but not sealing all of the spaces between crenels whereby liquid can flow from an annular space into the space about the fibers in the tubular member at one end of the tubular member and out of the space in the tubular member into the annular space at the opposite end of the tubular member, means for introducing dialysis fluid into one annular space, means for removing dialysis fluid from the other annular space to create flow of dialysis fluid in the tubular member about the fibers, convex disks having an annular prong near their peripheral edges impressed in said elastomeric composition radially outwardly from the fibers sealing a space between the disk and the end of the fiber bundle, said disks being end closure members for the tubular member, means for the flow of blood into one of the last said spaces and into the fibers, and means for the flow of blood from the second of the last said spaces.
Claim 3
Dependent Claim
262 words
A separating device, adapted for hemodialysis, comprising an elongated tubular housing, at least one bundle of a large number of parallel, hollow, selectively permeable fibers accommodated in said housing, whose ends are disposed adjacent the ends of the housing, supporting members embedding the ends of said hollow fibers, and formed of a solid synthetic polymeric casting composition filling voids about the ends of the fibers and sealing the ends of said tubular housing, a blood space provided by the inside of said hollow fibers, a dialysis space located inside said housing but outside said hollow fibers, inlets provided with said blood space and said dialysis space for the supply of blood and dialysis liquid thereto, respectively, which media can enter into exchange through the walls of said hollow fibers, outlets provided with said blood space and said dialysis space for the discharge of blood and dialysis liquid therefrom, respectively, at least one ring-like constriction substantially impassable to said dialysis liquid and placed in a manner wherein the exterior surface of said constriction contacts the inner wall of the dialysis space of said housing, at least part of said constriction being elastic, said elastic part bearing against said bundle and substantially extending in a circumferential direction about said bundle, but only partly along the length of the bundle(s), and convex disks having an annular prong near their peripheral edges impressed in said polymeric casting composition radially outwardly from the fibers sealing a space between a disk and the end of the fiber bundle, said disks being end closure members for the tubular housing.
Claim 4
Dependent Claim
262 words
A separating device, adapted for hemodialysis, comprising an elongated tubular housing, at least one bundle of a large number of parallel, hollow, selectively permeable fibers accommodated in said housing, whose ends are disposed adjacent the ends of the housing, supporting members embedding the ends of said hollow fibers, and formed of a solid synthetic polymeric casting composition filling voids about the ends of the fibers and sealing the ends of said tubular housing, a blood space provided by the inside of said hollow fibers, a dialysis space located inside said housing but outside said hollow fibers, inlets provided with said blood space and said dialysis space for the supply of blood and dialysis liquid thereto, respectively, which media can enter into exchange through the walls of said hollow fibers, outlets provided with said blood space and said dialysis space for the discharge of blood and dialysis liquid therefrom, respectively, at least one ring-like constriction substantially impassable to said dialysis liquid and placed in a manner wherein the exterior surface of said constriction contacts the inner wall of the dialysis space of said housing, at least part of said constriction being elastic, said elastic part bearing against said bundle and substantially extending in a circumferential direction about said bundle, but only partly along the length of the bundle(s), and convex disks having an annular prong near their peripheral edges impressed in said polymeric casting composition radially outwardly from the fibers sealing a space between a disk and the end of the fiber bundle, said disks being end closure members for the tubular housing.
Claim 5
Dependent Claim
37 words
A separating device according to claim 2, characterized in that the first medium passes through the first medium space and the second medium passes through the second medium space substantially in a longitudinal direction of the bundles.
Claim 6
Dependent Claim
18 words
A separating device according to claim 2, characterized in that the ring-like constriction is of an elastic material.
Claim 7
Dependent Claim
16 words
An apparatus according to claim 2, characterized in that the hollow fibers are of cupramonium cellulose.
Claim 8
Dependent Claim
20 words
An apparatus according to claim 2, characterized in that the hollow fibers have an outer diameter not exceeding 400 μm.
Claim 9
Dependent Claim
73 words
The separating device of claim 2, wherein the tubular housing comprises a middle portion ending in expanded end portions which form the outer walls of annular chambers connecting with the inlet and the outlet of the dialysis space, the inner walls of said annular chambers being provided with a number of circumferentially spaced passages by which the annular chambers communicate with the dialysis space, which inner walls partly extend into the supporting members.
Claim 10
Dependent Claim
22 words
An apparatus according to claim 7, characterized in that the inner walls of the annular chambers are provided with axially projecting crenels.
Claim 11
Dependent Claim
34 words
An apparatus according to claim 7, characterized in that the inner walls of the annular chambers are formed by parts of the middle portion of the housing extending to within the expanded end portions.
Claim 12
Dependent Claim
42 words
An apparatus according to claim 7, characterized in that the housing comprises an outer sleeve inside which there is positioned a separate inner sleeve and the inner walls of the annular chambers are formed by the crenellated ends of the inner sleeve.
Claim 13
Dependent Claim
45 words
A device for hemodialysis in which the first space communicates with two blood distribution chambers that connect with an inlet and an outlet for blood according to claim 7, characterized in that the annular chambers connect with an inlet and an outlet for dialysis liquid.
Claim 14
Dependent Claim
30 words
An apparatus according to claim 7, characterized in that the inlet opening of the second space is formed by the mouth of a feed channel directed transverse to the bundle.
Claim 15
Dependent Claim
35 words
An apparatus according to claim 12, characterized in that the mouth of the feed channel is positioned opposite a part of the inner wall of an annular chamber, which part is located between two passages.
Claim 16
Dependent Claim
30 words
An apparatus according to claim 7, characterized in that the outlet opening of the second space is formed by the mouth of a discharge channel directed transverse to the bundle.
Claim 17
Dependent Claim
35 words
An apparatus according to claim 14, characterized in that the mouth of the discharge channel is positioned opposite a part of the inner wall of an annular chamber, which part is located between two passages.
Claim 18
Dependent Claim
20 words
An apparatus according to claim 7, characterized in that the hollow fibers have a wall thickness not exceeding 100 μm.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-26 | 1984-02-25 | 1984-08-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-26 | 1988-02-25 | 1988-08-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-26 | 1992-02-25 | 1992-08-26 | $7700.00 | Window Closed / Lapsed |