Patent US4218463A successfully refreshed from Google Patents.
US4218463A
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3-Substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Assignee: Merck and Co Inc
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Filing: 1977-12-28
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Granted: 1980-08-19
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Expires: 1997-12-28
Abstract
Abstract Disclosed are 3-substituted thio-6-amido-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acids having the structure: <IMAGE> wherein: R1 is hydrogen or acyl and R8 is, inter alia, independently selected from the group consisting of hydrogen, alkyl, alkenyl, aryl and aralkyl. Such compounds as well as their pharmaceutically acceptable salt, ester and amide derivatives are useful as antibiotics. Also disclosed are processes for the preparation of such compounds, pharmaceutical compositions comprising such compounds and methods of treatment comprising administering such compounds and compositions when an antibiotic effect is indicated.
Inventors
- 👤 Burton G. Christensen
- 👤 Ravindra N. Guthikonda
- 👤 David B. R. Johnston
- 👤 Susan M. Schmitt
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 21:55
CPC Classifications
C; C07; C07D; C07D205/00; C07D205/02; C07D205/06; C07D205/08; C07D205/085; C07D477/00; C07D477/10; C07D477/24; C07F; C07F7/00; C07F7/02; C07F7/08; C07F7/10
Claims Analysis
Total Claims: 4
Claim 1
Independent Claim
61 words
A compound having the structure: ##STR98## and the pharmaceutically acceptable salts thereof wherein R is H, a pharmaceutically acceptable salt cation or lower alkyl having 1-4 carbon atoms, lower alkenyl having 1-4 carbon atoms, benzyl, p-nitrobenzyl, pivaloyloxy methyl, 3-phthalidyl, or phenacyl; and R 8 is selected from the group consisting of ##STR99## R 1 is hydrogen, thienylacetyl, phenylacetyl, ##STR100## or o-nitrophenylacetyl.
Claim 2
Dependent Claim
61 words
A compound having the structure: ##STR98## and the pharmaceutically acceptable salts thereof wherein R is H, a pharmaceutically acceptable salt cation or lower alkyl having 1-4 carbon atoms, lower alkenyl having 1-4 carbon atoms, benzyl, p-nitrobenzyl, pivaloyloxy methyl, 3-phthalidyl, or phenacyl; and R 8 is selected from the group consisting of ##STR99## R 1 is hydrogen, thienylacetyl, phenylacetyl, ##STR100## or o-nitrophenylacetyl.
Claim 3
Dependent Claim
10 words
A compound according to claim 1 having the structure: ##STR101##
Claim 4
Dependent Claim
21 words
An antibiotic pharmaceutical composition comprising a therapeutically effective amount of a compound according to claim 1 and a pharmaceutical carrier therefor.
References Cited (Backward Citations)
US3950357A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-19 | 1984-02-18 | 1984-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-19 | 1988-02-18 | 1988-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-19 | 1992-02-18 | 1992-08-19 | $7700.00 | Window Closed / Lapsed |