US4218461A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2,3-Dihydro-2-[(1H-imidazol-1-yl)-methylene]-1H-inden-1-ones
Assignee: ER Squibb and Sons LLC
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Filing: 1979-08-15
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Granted: 1980-08-19
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Expires: 1999-08-15
Abstract
Abstract New 2,3-dihydro-2-[(1H-imidazol-1-yl)-methylene]-1H-inden-1-ones are provided having the general formula ##STR1## wherein R, R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different and each is hydrogen, lower alkyl, halogen, lower alkoxy, lower alkylthio, phenyl-lower alkyl, phenyl or substituted phenyl. The above compounds and their salts are useful as antifungal and antibacterial agents.
Inventors
- 👤 Hans Hoehn
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 09:52
CPC Classifications
C; C07; C07D; C07D231/00; C07D231/02; C07D231/10; C07D231/12; C07C; C07C205/00; C07C205/45; C07C45/00; C07C45/61; C07C45/67; C07C45/68; C07C49/00; C07C49/587; C07C49/703; C07C49/747; C07C49/753; C07D233/00; C07D233/54; C07D233/56; C07D249/00; C07D249/02; C07D249/08
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
70 words
A compound of the formula ##STR10## wherein R, R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different and each is hydrogen, lower alkyl, halogen, lower alkoxy, lower alkylthio, phenyl-lower alkyl, phenyl or substituted phenyl, wherein the phenyl bears one halogen, hydroxy, lower alkoxy, lower alkyl, lower alkylthio, cyano or nitro group; and non-toxic physiologically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
70 words
A compound of the formula ##STR10## wherein R, R 1 , R 2 , R 3 , R 4 and R 5 may be the same or different and each is hydrogen, lower alkyl, halogen, lower alkoxy, lower alkylthio, phenyl-lower alkyl, phenyl or substituted phenyl, wherein the phenyl bears one halogen, hydroxy, lower alkoxy, lower alkyl, lower alkylthio, cyano or nitro group; and non-toxic physiologically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
14 words
The compound as defined in claim 1 wherein R and R 1 are hydrogen.
Claim 4
Dependent Claim
31 words
The compound as defined in claim 1 wherein one of R and R 1 is lower alkyl, phenyl, or phenyl containing one or two halo substituents and the other is hydrogen.
Claim 5
Dependent Claim
27 words
The compound as defined in claim 3 wherein one of R 2 , R 3 , R 4 and R 5 is chlorine and the remainder hydrogen.
Claim 6
Dependent Claim
14 words
The compound as defined in claim 1 in the form of its hydrochloride salt.
Claim 7
Dependent Claim
15 words
The compound as defined in claim 1 having the name 2,3-dihydro-2-[(1H-imidazol-1-yl)methylene]-1H-inden-1-one or its hydrochloride salt.
Claim 8
Dependent Claim
11 words
The compound as defined in claim 1 having the name 6-chloro-2,3-dihydro-2-(1H-imidazol-1-ylmethylene)-1H-inden-1-one.
Claim 9
Dependent Claim
11 words
The compound as defined in claim 1 having the name 2,3-dihydro-2-(1H-imidazol-1-ylmethylene)-3-phenyl-1H-inden-1-one.
Claim 10
Dependent Claim
11 words
The compound as defined in claim 1 having the name 6-chloro-3-(4-chlorophenyl)-2,3-dihydro-2-(1H-imidazol-1-ylmethylene)-1H-inden-1-one.
Claim 11
Dependent Claim
11 words
The compound as defined in claim 1 having the name 4,6-dichloro-3-(2,4-dichlorophenyl)-2,3-dihydro-2-(1H-imidazol-1-ylmethylene)-1H-inden-1-one.
Claim 12
Dependent Claim
11 words
The compound as defined in claim 1 having the name 2,3-dihydro-2-(1H-imidazol-1-ylmethylene)-3-methyl-1H-inden-1-one.
Claim 13
Dependent Claim
11 words
The compound as defined in claim 1 having the name 4-chloro-2,3-dihydro-2-(1H-imidazol-1-ylmethylene)-1H-inden-1-one.
Claim 14
Dependent Claim
21 words
An antimicrobial composition comprising an effective amount of a compound as defined in claim 1 and a pharmaceutically acceptable carrier therefor.
Claim 15
Dependent Claim
28 words
A method for treating bacterial or fungal infections in mammals which comprises administering to a mammalian host an effective amount of a compound as defined in claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-08-19 | 1984-02-18 | 1984-08-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-08-19 | 1988-02-18 | 1988-08-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-08-19 | 1992-02-18 | 1992-08-19 | $7700.00 | Window Closed / Lapsed |