US3991201A
Expired / Lapsed
US
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1-(β-Aryl-β-R-ethyl)imidazoles as antimicrobial agents
Assignee: Janssen Pharmaceutica NV
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Filing: 1975-05-19
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Granted: 1976-11-09
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Expires: 1995-05-19
Abstract
Abstract Compounds of the class of 1-(β-aryl-β-R-ethyl)imidazoles, useful as antibacterial and antifungal agents.
Inventors
- 👤 Jan Heeres
- 👤 Leo J. J. Backx
- 👤 Joseph H. Mostmans
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 21:24
CPC Classifications
A; A01; A01N; A01N43/00; A01N43/48; A01N43/50
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
131 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##SPC3## and the therapeutically active non-toxic acid addition salts thereof, wherein: Ar is a member selected from the group consisting of phenyl, mono-, di- and trihalophenyl, loweralkylphenyl, loweralkyloxyphenyl, nitrophenyl, cyanophenyl and trifluoromethylphenyl; and R is a member selected from the group consisting of alkyl having from 1 to 10 carbons, cycloalkyl having from 3 to 6 carbon atoms, lower alkenyl, aryl-loweralkyl, aryl-loweralkenyl, said aryl being a member selected from the group consisting of phenyl, mono-, di- and tri-halophenyl, loweralkylphenyl, loweralkyloxyphenyl, nitrophenyl, cyanophenyl and trifluoromethylphenyl.
Claim 2
Dependent Claim
131 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##SPC3## and the therapeutically active non-toxic acid addition salts thereof, wherein: Ar is a member selected from the group consisting of phenyl, mono-, di- and trihalophenyl, loweralkylphenyl, loweralkyloxyphenyl, nitrophenyl, cyanophenyl and trifluoromethylphenyl; and R is a member selected from the group consisting of alkyl having from 1 to 10 carbons, cycloalkyl having from 3 to 6 carbon atoms, lower alkenyl, aryl-loweralkyl, aryl-loweralkenyl, said aryl being a member selected from the group consisting of phenyl, mono-, di- and tri-halophenyl, loweralkylphenyl, loweralkyloxyphenyl, nitrophenyl, cyanophenyl and trifluoromethylphenyl.
Claim 3
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)hexyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 4
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)hexyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 5
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)decyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 6
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)decyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 7
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)-4-methylpentyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 8
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)-4-methylpentyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 9
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[3-(2-chlorophenyl)-2-(2,4-dichlorophenyl)propyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 10
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[3-(2-chlorophenyl)-2-(2,4-dichlorophenyl)propyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 11
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-(2-cyclohexyl-2-phenylethyl)-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 12
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-(2-cyclohexyl-2-phenylethyl)-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 13
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[2-(2-chlorophenyl)-octyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 14
Dependent Claim
42 words
A composition for deterring the growth of a microorganism selected from the group consisting of fungus and bacterium comprising an inert carrier material and as an active ingredient an antimicrobially effective amount of 1-[2-(2-chlorophenyl)-octyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 15
Independent Claim
131 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##SPC4## and the therapeutically active non-toxic acid addition salts thereof, wherein: Ar is a member selected from the group consisting of phenyl, mono-, di- and trihalophenyl, loweralkylphenyl, loweralkyloxyphenyl, nitrophenyl, cyanophenyl and trifluoromethylphenyl; and R is a member selected from the group consisting of alkyl, having from 1 to 10 carbon atoms, cycloalkyl, having from 3 to 6 carbon atoms, lower alkenyl, aryl-loweralkyl, aryl-loweralkenyl, said aryl being a member selected from the group consisting of phenyl, mono-, di- and trihalophenyl, loweralkylphenyl, loweralkyloxyphenyl, nitrophenyl, cyanophenyl and trifluoromethylphenyl.
Claim 16
Independent Claim
131 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of a compound selected from the group consisting of an imidazole derivative having the formula: ##SPC4## and the therapeutically active non-toxic acid addition salts thereof, wherein: Ar is a member selected from the group consisting of phenyl, mono-, di- and trihalophenyl, loweralkylphenyl, loweralkyloxyphenyl, nitrophenyl, cyanophenyl and trifluoromethylphenyl; and R is a member selected from the group consisting of alkyl, having from 1 to 10 carbon atoms, cycloalkyl, having from 3 to 6 carbon atoms, lower alkenyl, aryl-loweralkyl, aryl-loweralkenyl, said aryl being a member selected from the group consisting of phenyl, mono-, di- and trihalophenyl, loweralkylphenyl, loweralkyloxyphenyl, nitrophenyl, cyanophenyl and trifluoromethylphenyl.
Claim 17
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)hexyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 18
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)hexyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 19
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)decyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 20
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)decyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 21
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)-4-methylpentyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 22
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[2-(2,4-dichlorophenyl)-4-methylpentyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 23
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[3-(2-chlorophenyl)-2-(2,4-dichlorophenyl)propyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 24
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[3-(2-chlorophenyl)-2-(2,4-dichlorophenyl)propyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 25
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-(2-cyclohexyl-2-phenylethyl)-1-H-imidazole or the therapeutically active acid addition salts thereof.
Claim 26
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-(2-cyclohexyl-2-phenylethyl)-1-H-imidazole or the therapeutically active acid addition salts thereof.
Claim 27
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[2-(2-chlorophenyl)-octyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
Claim 28
Independent Claim
41 words
The method of deterring the growth of a microorganism selected from the group consisting of fungus and bacterium which comprises subjecting said microorganism to the action of an antimicrobially effective amount of 1-[2-(2-chlorophenyl)-octyl]-1H-imidazole or the therapeutically active acid addition salts thereof.
References Cited (Backward Citations)
FR1487326A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-11-09 | 1980-05-10 | 1980-11-09 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-11-09 | 1984-05-10 | 1984-11-09 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-11-09 | 1988-05-10 | 1988-11-09 | $7700.00 | Window Closed / Lapsed |