ω-Aminocarboxylic acid amides

Abstract

Abstract The invention relates to novel ω-aminocarboxylic acid amides having the formula (I) ##STR1## wherein A is --SO 2 OH or --OPO(OH) 2 , R 1 is hydrogen, an acyl group, such as benzoyl, arylsulfonyl, alkoxycarbonyl, cycloalkoxycarbonyl or aralkoxycarbonyl group or an aralkoxycarbonyl group having a halogen, alkoxy, nitro, phenylazo or alkoxyphenylazo substituent, alkyl-substituted aryloxycarbonyl or carbonyl, R 2 is hydrogen or a carbonyl group, with the proviso that when R 1 and R 2 each stand for carbonyl, the two carbonyl groups form a ring through an intervening o-phenylene, alkylene or vinylene group when A is --SO 2 OH and R 1 is an acyl group such as benzoyl, aryl sulfonyl, alkoxy-carbonyl, cycloalkoxycarbonyl or aryloxycarbonyl group or an aralkoxy carbonyl group having a halogen, alkoxy, nitro, phenylozo or alkoxyphenylazo substituent or an alkyl-substituted aryloxycarbonyl group or carbonyl group, R 2 is hydrogen or a carbonyl group, with the proviso that when R 1 and R 2 each stand for carbonyl, the two carbonyl groups form a ring through an intervening o-phenylene, alkylene or vinylene group when A is --O--P--O(OH) 2 and n is equal to 2 or 3, and salts of the above compounds, furthermore to a process for the preparation thereof. The novel compounds according to the invention possess valuable pharmacological effects in reducing blood sugar levels or can be applied as intermediate in the synthesis of biologically active compounds.

Inventors

• 👤 Laszlo Feuer
• 👤 Arpad Furka
• 👤 Ferenc Sebestyen
• 👤 Aniko Horvath
• 👤 nee Szepespataki Jolan Hercsel

Bibliographic Details