Patent US4215036A successfully refreshed from Google Patents.
US4215036A
Expired / Lapsed
US
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Modified grass pollen antigens
Assignee: Research Corp
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Filing: 1978-08-15
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Granted: 1980-07-29
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Expires: 1998-08-15
Abstract
Abstract Oxidative rearrangement and cleavage of hydroxy aromatic rings of quercitin moiety of Timothy grass pollen antigen or antigen fragments gives rise to a modified antigen having no antigenic properties but retaining capability of activating T-cells for regulation of immune response. The invention includes the modified antigens, the method of oxidative cleavage, immunotherapeutic methods for alleviating allergic responses to the Timothy grass pollen antigens and immunotherapeutic compositions therefor.
Inventors
- 👤 Arthur Malley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 21:07
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/35; A61K39/36; Y; Y10; Y10S; Y10S530/00; Y10S530/806
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
86 words
A method for modifying the antigenic properties of a quercitin moiety containing grass pollen antigen or fragment thereof having the structure: ##STR4## wherein: G represents glucose, and T represents threonine or a poly-peptide linked to said structure through a threonine molecule; comprising subjecting said antigen to oxidative conditions such that the said dihydroxy aromatic rings undergo rearrangement and ring scission without substantially modifying said threonine or polypeptide to yield a product substantially devoid of antigenic properties but capable of activating T-cells and inducing T s cells.
Claim 2
Independent Claim
86 words
A method for modifying the antigenic properties of a quercitin moiety containing grass pollen antigen or fragment thereof having the structure: ##STR4## wherein: G represents glucose, and T represents threonine or a poly-peptide linked to said structure through a threonine molecule; comprising subjecting said antigen to oxidative conditions such that the said dihydroxy aromatic rings undergo rearrangement and ring scission without substantially modifying said threonine or polypeptide to yield a product substantially devoid of antigenic properties but capable of activating T-cells and inducing T s cells.
Claim 3
Dependent Claim
28 words
The method of claim 1 wherein said grass pollen antigen is antigen B, antigen D, antigen D 1 , antigen D 2 , or antigen D 3 .
Claim 4
Dependent Claim
31 words
The method of claim 1 wherein said oxidative conditions also result in the rearrangement and ring scission of the hydroxy aromatic ring present in the tyrosine moiety of said poly-peptide T.
Claim 5
Dependent Claim
34 words
The method of claim 1 wherein the extent of said oxidation is sufficient to result in a modified antigen incapable of reacting with antibodies directed against the antigenic determinant structure of said starting antigen.
Claim 6
Dependent Claim
24 words
The method of claim 4 wherein said oxidative conditions are such that substantial modification of the amino acid content of said antigen is avoided.
Claim 7
Dependent Claim
11 words
The method of claim 1 wherein said grass pollen is photooxidized.
Claim 8
Dependent Claim
27 words
The method of claim 6 wherein said photooxidation is effected by saturating an aqueous solution of said antigen with oxygen and then exposing said solution to light.
Claim 9
Dependent Claim
12 words
The modified grass pollen antigen produced by the process of claim 1.
Claim 10
Dependent Claim
12 words
The modified grass pollen antigen produced by the process of claim 2.
Claim 11
Dependent Claim
12 words
The modified grass pollen antigen produced by the process of claim 5.
Claim 12
Dependent Claim
12 words
The modified grass pollen antigen produced by the process of claim 6.
Claim 13
Dependent Claim
12 words
The modified grass pollen antigen produced by the process of claim 7.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-07-29 | 1984-01-28 | 1984-07-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-07-29 | 1988-01-28 | 1988-07-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-07-29 | 1992-01-28 | 1992-07-29 | $7700.00 | Window Closed / Lapsed |