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US4213989A
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Anorexigenic 3-phenyl-tetrahydropyridines
Assignee: Sanofi Aventis France
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Filing: 1979-02-02
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Granted: 1980-07-22
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Expires: 1999-02-02
Abstract
Abstract Novel 3-phenyl-tetrahydropyridines of the formula ##STR1## wherein X is selected from the group consisting of hydrogen and chlorine and R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl and alkynyl of 3 to 5 carbon atoms and phenyl alkyl of 1 to 3 alkyl carbon atoms with the proviso that X is not hydrogen when R is benzyl and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable anorexigenic properties and inhibition of serontine collection both in vivo and in vitro and their preparation and novel intermediates.
Inventors
- 👤 Lucien Nedelec
- 👤 Jacques Guillaume
- 👤 Claude Dumont
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 23:22
CPC Classifications
C; C07; C07F; C07F3/00; C07F3/02; A; A61; A61P; A61P25/00; A61P25/24; A61P25/26; A61P3/00; A61P3/04; C07D; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/40; C07D211/42; C07D211/68; C07D211/70
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
102 words
A method of curbing the appetite of warm-blooded animals comprising administering to warm-blooded animals an anorexigenically effective amount of at least one compound selected from the group consisting of 3-phenyl-tetrahydro-pyridines of the formula ##STR14## wherein X is selected from the group consisting of hydrogen and chlorine and R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl and alkynyl of 3 to 5 carbon atoms and phenyl alkyl of 1 to 3 alkyl carbon atoms with the proviso that X is not hydrogen when R is benzyl and their non-toxic, pharmaceutically acceptable acid addition salts.
Claim 2
Independent Claim
102 words
A method of curbing the appetite of warm-blooded animals comprising administering to warm-blooded animals an anorexigenically effective amount of at least one compound selected from the group consisting of 3-phenyl-tetrahydro-pyridines of the formula ##STR14## wherein X is selected from the group consisting of hydrogen and chlorine and R is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, alkenyl and alkynyl of 3 to 5 carbon atoms and phenyl alkyl of 1 to 3 alkyl carbon atoms with the proviso that X is not hydrogen when R is benzyl and their non-toxic, pharmaceutically acceptable acid addition salts.
Claim 3
Dependent Claim
9 words
The method of claim 1 wherein X is hydrogen.
Claim 4
Dependent Claim
17 words
The method of claim 2 wherein R is hydrogen or alkyl of 1 to 5 carbon atoms.
Claim 5
Dependent Claim
11 words
A method of claim 1 which is the hydrochloride of 3-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydropyridine.
Claim 6
Dependent Claim
11 words
A method of claim 1 which is the hydrochloride of 1-propyl-3-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydropyridine.
Claim 7
Dependent Claim
11 words
A method of claim 1 which is the hydrochloride of 1-isopropyl-3-(3-trifluoromethyl-phenyl)-1,2,5,6-tetrahydropyridine.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-07-22 | 1984-01-21 | 1984-07-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-07-22 | 1988-01-21 | 1988-07-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-07-22 | 1992-01-21 | 1992-07-22 | $7700.00 | Window Closed / Lapsed |