Abstract What is disclosed is a pearl polymer product, a method of making the same, and the use thereof as a carrier for biologically active materials, said product being composed of hollow pearl particles having a diameter from 5 to 1000 microns and consisting of a cross-linked polymer which is a cross-linked homopolymer or copolymer comprising at least one member selected from the group consisting of acrylamide, methacrylamide, methylene-bis-acrylamide and methylene-bis-methacrylamide, said polymer containing at least 5 percent by weight of a monomer having at least two carbon-carbon double bonds which are activated by a neighboring phenyl group or carbonyl group, said polymer further being of a composition such that x+3y≧40, where x is the percent by weight in the polymer of acrylamide and methacrylamide and y is the percent by weight in the polymer of methylene-bis-acrylamide and methylene-bis-methacrylamide.
A pearl polymer product having a protein bonded thereto, said pearl polymer product being composed of hollow pearl particles having a diameter from 5 to 1000 microns and consisting of a cross-linked copolymer comprising at least one member selected from the group consisting of acrylamide, methacrylamide, methylene-bis-acrylamide and methylene-bis-methacrylamide, and additionally comprising a free-radically-copolymerizable monomer having a group by which said copolymer is covalently bonded to a primary amino group or a hydroxy group of said protein, said polymer containing at least 5 percent by weight of a monomer having at least two carbon-carbon double bonds which are activated by a neighboring phenyl group or carbonyl group, said polymer further being of a composition such that x+3y≧40, where x is the percent by weight in the polymer of acrylamide and methacrylamide and y is the percent by weight in the polymer of methylene-bis-acrylamide and methylene-bis-methacrylamide.
Claim 2
Dependent Claim
145 words
A pearl polymer product having a protein bonded thereto, said pearl polymer product being composed of hollow pearl particles having a diameter from 5 to 1000 microns and consisting of a cross-linked copolymer comprising at least one member selected from the group consisting of acrylamide, methacrylamide, methylene-bis-acrylamide and methylene-bis-methacrylamide, and additionally comprising a free-radically-copolymerizable monomer having a group by which said copolymer is covalently bonded to a primary amino group or a hydroxy group of said protein, said polymer containing at least 5 percent by weight of a monomer having at least two carbon-carbon double bonds which are activated by a neighboring phenyl group or carbonyl group, said polymer further being of a composition such that x+3y≧40, where x is the percent by weight in the polymer of acrylamide and methacrylamide and y is the percent by weight in the polymer of methylene-bis-acrylamide and methylene-bis-methacrylamide.
Claim 3
Dependent Claim
19 words
A pearl polymer product having a protein bonded thereto as in claim 1 wherein said protein is an enzyme.
Claim 4
Dependent Claim
19 words
A pearl polymer product having a protein bonded thereto as in claim 1 wherein said protein is an immunoglobulin.