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US4206137A
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Thioalkanoylalkanoic acid compounds
Assignee: ER Squibb and Sons LLC
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Filing: 1978-11-20
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Granted: 1980-06-03
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Expires: 1998-11-20
Abstract
Abstract Thioalkanoylalkanoic acid compounds and salts thereof having the formula <IMAGE> wherein R1, R2, R3 and R4 each is hydrogen or lower alkyl; R5 is hydrogen, lower alkanoyl, benzoyl or <IMAGE> A and B each is hydrogen or join together as a polymethylene chain -(CH2)n- to complete a 4-, 5- or 6- membered cycloalkyl group, and m is 0 or 1, are angiotensin converting enzyme inhibitors and are useful as hypotensive agents.
Inventors
- 👤 Michael E. Condon
- 👤 Miguel A. Ondetti
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 01:11
CPC Classifications
C; C07; C07C; C07C323/00; C07C323/50; C07C323/51; C07C323/53; C07C323/52; C07C327/00; C07C327/20; C07C327/32; C07C2601/00; C07C2601/04; C07C2601/06; C07C2601/08; C07C2601/12; C07C2601/14
Claims Analysis
Total Claims: 28
Claim 1
Independent Claim
54 words
A compound of the formula ##STR18## wherein R 1 , R 2 , R 3 and R 4 each is hydrogen or lower alkyl; R 5 is ##STR19## A and B each is hydrogen or join together to complete a cycloalkyl ring of 4 to 6 carbons; each m is one; and salts thereof.
Claim 2
Dependent Claim
54 words
A compound of the formula ##STR18## wherein R 1 , R 2 , R 3 and R 4 each is hydrogen or lower alkyl; R 5 is ##STR19## A and B each is hydrogen or join together to complete a cycloalkyl ring of 4 to 6 carbons; each m is one; and salts thereof.
Claim 3
Dependent Claim
47 words
A compound of the formula ##STR20## wherein R 1 , R 2 , R 3 and R 4 each is hydrogen or lower alkyl; R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR21## m is 0 or 1; n is 2, 3 or 4; and salts thereof.
Claim 4
Dependent Claim
47 words
A compound of the formula ##STR20## wherein R 1 , R 2 , R 3 and R 4 each is hydrogen or lower alkyl; R 5 is hydrogen, lower alkanoyl, benzoyl or ##STR21## m is 0 or 1; n is 2, 3 or 4; and salts thereof.
Claim 5
Dependent Claim
44 words
A compound as in claim 2 wherein R 1 , R 2 , R 3 and R 4 each is hydrogen or lower alkyl; R 5 is hydrogen, lower alkanoyl or benzoyl, m is 1; n is 2, 3 or 4; and salts thereof.
Claim 6
Dependent Claim
10 words
A compound as in claim 3 wherein n is 3.
Claim 7
Dependent Claim
10 words
A compound as in claim 3 wherein n is 2.
Claim 8
Dependent Claim
10 words
A compound as in claim 3 wherein n is 4.
Claim 9
Dependent Claim
24 words
A compound as in claim 3 wherein R 1 , R 2 , R 3 , R 4 and R 5 each is hydrogen.
Claim 10
Dependent Claim
27 words
A compound as in claim 3 wherein R 1 , R 2 , R 3 and R 4 each is hydrogen and R 5 is lower alkanoyl.
Claim 11
Dependent Claim
29 words
A compound as in claim 3 wherein n is 2 and and R 1 , R 2 , R 3 , R 4 and R 5 each is hydrogen.
Claim 12
Dependent Claim
28 words
A compound as in claim 3 wherein n is 3 and R 1 , R 2 , R 3 , R 4 and R 5 each is hydrogen.
Claim 13
Dependent Claim
28 words
A compound as in claim 3 wherein n is 4 and R 1 , R 2 , R 3 , R 4 and R 5 each is hydrogen.
Claim 14
Dependent Claim
12 words
A compound as in claim 3 wherein R 2 is lower alkyl.
Claim 15
Dependent Claim
16 words
A compound as in claim 3 wherein R 3 and R 4 each is lower alkyl.
Claim 16
Dependent Claim
29 words
A compound as in claim 3 wherein n is 4, R 1 , R 3 , R 4 and R 5 each is hydrogen; and R 2 is methyl.
Claim 17
Dependent Claim
30 words
A compound as in claim 3 wherein n is 3; R 1 , R 2 and R 5 each is hydrogen and R 3 and R 4 each is methyl.
Claim 18
Dependent Claim
34 words
A compound as in claim 1 wherein each R 1 , R 2 , R 3 and R 4 is hydrogen; each m is 1; A and B join to complete a cyclohexane ring.
Claim 19
Dependent Claim
24 words
A compound as in claim 2 wherein R 1 ,R 2 and R 5 each is hydrogen; m is 0; and n is 4.
Claim 20
Dependent Claim
34 words
A compound of the formula ##STR22## wherein R 2 , R 3 , R 4 and n have the same meaning as in claim 2 and R is hydrogen, phenyl-lower alkyl or diphenyl-lower alkyl.
Claim 21
Dependent Claim
26 words
A compound as in claim 18 wherein R and R 2 each is hydrogen; R 3 and R 4 each is methyl and n is 3.
Claim 22
Dependent Claim
23 words
A compound as in claim 18 wherein R, R 2 , R 3 and R 4 each is hydrogen and n is 4.
Claim 23
Dependent Claim
26 words
A compound as in claim 18 wherein R is diphenylmethyl; R 2 and R 4 each is hydrogen; R 3 is methyl; and n is 4.
Claim 24
Dependent Claim
25 words
A compound as in claim 18 wherein R is diphenylmethyl; R 2 , R 3 and R 4 each is hydrogen; and n is 3.
Claim 25
Dependent Claim
23 words
A compound as in claim 18 wherein R, R 2 , R 3 and R 4 each is hydrogen and n is 2.
Claim 26
Dependent Claim
34 words
A compound of the formula ##STR23## wherein A and B each is hydrogen or join together to complete a cycloalkyl ring of 4 to 6 carbons; m is 0 or 1; and salts thereof.
Claim 27
Dependent Claim
34 words
A compound of the formula ##STR23## wherein A and B each is hydrogen or join together to complete a cycloalkyl ring of 4 to 6 carbons; m is 0 or 1; and salts thereof.
Claim 28
Dependent Claim
16 words
A compound of claim 24 wherein A and B are both hydrogen and m is 1.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-06-03 | 1983-12-03 | 1984-06-03 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-06-03 | 1987-12-03 | 1988-06-03 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-06-03 | 1991-12-03 | 1992-06-03 | $7700.00 | Window Closed / Lapsed |