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US4205089A Expired / Lapsed US ⏱️ 0.0 years remaining

Solvent vehicle for the parenteral administration of therapeutics

Assignee: ACF Chemiefarma NV
•
Filing: 1979-01-16
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Granted: 1980-05-27
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Expires: 1999-01-16
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Abstract

Abstract The invention relates to a solvent vehicle for therapeutics comprising a dialkyl ester of adipic acid and, optionally, DMSO, which is particularly useful for therapeutic materials having a low solubility or being insoluble in water. The invention further relates to pharmaceutical compositions which are suitable for parenteral administration, especially by intramuscular injection, comprising a therapeutically active material dissolved in said solvent vehicle. Solvent vehicles containing di-n-butyl adipate and DMSO and, if desired, one or more adjuvants, are preferred. Particularly useful are pharmaceutical compositions for the prophylaxis and/or treatment of diseases caused by internal parasites, which can be administered by intramuscular injection. A preferred embodiment of the invention is an injectable composition against distomatosis (liver fluke disease) containing proportionally 12.5 g 4,6'-dichloro-4',6-dinitro-2,2'-methylene-diphenol and 30 g of DMSO, completed with di-n-butyl adipate to 100 cm 3 .

Inventors

  • 👤 Cornelis A. Ladage
  • 👤 Douwe J. van Linge
  • 👤 Huibert A. van Riessen

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-03 20:51
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/06; A61K47/20; A61K47/08; A61K47/14; A61K9/00; A61K9/0012; A61K9/0019

Claims Analysis

Total Claims: 5
Claim 1
Independent Claim 51 words
A solvent vehicle for the parenteral administration of therapeutics, said vehicle comprising DMSO and a symmetric or unsymmetric ester of adipic acid wherein both alkyl groups together contain six to twelve carbon atoms and wherein the smaller alkyl group present if said ester is unsymmetric contains at least two carbon atoms.
Claim 2
Dependent Claim 51 words
A solvent vehicle for the parenteral administration of therapeutics, said vehicle comprising DMSO and a symmetric or unsymmetric ester of adipic acid wherein both alkyl groups together contain six to twelve carbon atoms and wherein the smaller alkyl group present if said ester is unsymmetric contains at least two carbon atoms.
Claim 3
Dependent Claim 16 words
A solvent vehicle as in claim 1 wherein said ester of adipic acid is di-n-butyl adipate.
Claim 4
Dependent Claim 26 words
A solvent vehicle as in claim 1 comprising from 50 to 95 percent w/v of di-n-butyl adipate and from 5 to 50 percent w/v of DMSO.
Claim 5
Dependent Claim 14 words
A solvent vehicle as in claim 1 which additionally comprises one or more adjuvants.

References Cited (Backward Citations)

US3743727A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1983-05-27 1983-11-26 1984-05-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1987-05-27 1987-11-26 1988-05-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1991-05-27 1991-11-26 1992-05-27 $7700.00 Window Closed / Lapsed

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