Patent US4205071A successfully refreshed from Google Patents.
US4205071A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Pharmaceutical compositions having immunosuppressant activity and methods therefor
Assignee: Smith Kline & French Laboratories Ltd
•
Filing: 1977-11-21
•
Granted: 1980-05-27
•
Expires: 1997-11-21
Abstract
Abstract S-(Aminoalkyl)isothioureas which have immunosuppressant activity. Two specific compounds are 2-(3-dimethylaminopropylthio)-2-imidazoline and N,N'-dimethyl-S-(3-dimethylaminopropyl)isothiourea.
Inventors
- 👤 Graham J. Durant
- 👤 Charon R. Ganellin
- 👤 Margaret R. Vickers
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 02:43
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/08; C07D295/084; C07D295/088; C07C; C07C335/00; C07C335/30; C07C335/32; C07D233/00; C07D233/04; C07D233/28; C07D233/30; C07D233/42
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
92 words
An isothiourea derivative of the Formula: ##STR3## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group wherein x is 2, 3 or 4; provided that when n is 2, R 3 and R 4 must be such that together they form a (CH 2 ) 4 group; and the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
92 words
An isothiourea derivative of the Formula: ##STR3## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group wherein x is 2, 3 or 4; provided that when n is 2, R 3 and R 4 must be such that together they form a (CH 2 ) 4 group; and the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
12 words
An isothiourea according to claim 1 wherein n is 2 or 3.
Claim 4
Dependent Claim
39 words
An isothiourea according to claim 1 wherein n is 3; R 1 and R 2 are lower alkyl; and R 3 and R 4 together with the two nitrogen atoms and the carbon atom shown form an imidazoline ring.
Claim 5
Dependent Claim
27 words
An isothiourea according to claim 1 wherein R 3 and R 4 together with the two nitrogen atoms and the carbon atom shown form an imidazoline ring.
Claim 6
Independent Claim
85 words
A method of producing immunosuppressant activity by administering to an animal in need thereof an effective amount of an isothiourea of the formula: ##STR4## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group where x is 2, 3 or 4, or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Independent Claim
85 words
A method of producing immunosuppressant activity by administering to an animal in need thereof an effective amount of an isothiourea of the formula: ##STR4## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group where x is 2, 3 or 4, or a pharmaceutically acceptable acid addition salt thereof.
Claim 8
Independent Claim
86 words
A method of treating rheumatoid arthritis by administering to an animal in need thereof an effective amount of an isothiourea derivative of the formula: ##STR5## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group where x is 2, 3 or 4, or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Independent Claim
86 words
A method of treating rheumatoid arthritis by administering to an animal in need thereof an effective amount of an isothiourea derivative of the formula: ##STR5## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group where x is 2, 3 or 4, or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Independent Claim
85 words
A method of treating psoriasis by administering to an animal in need thereof a therapeutically effective amount of an isothiourea of the formula: ##STR6## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group where x is 2, 3 or 4, or a pharmaceutically acceptable acid addition salt thereof.
Claim 11
Independent Claim
85 words
A method of treating psoriasis by administering to an animal in need thereof a therapeutically effective amount of an isothiourea of the formula: ##STR6## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group where x is 2, 3 or 4, or a pharmaceutically acceptable acid addition salt thereof.
Claim 12
Independent Claim
84 words
A method of reducing inflammation by administering to an animal in need thereof a therapeutically effective amount of an isothiourea of the formula: ##STR7## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group where x is 2, 3 or 4, or a pharmaceutically acceptable acid salt thereof.
Claim 13
Independent Claim
84 words
A method of reducing inflammation by administering to an animal in need thereof a therapeutically effective amount of an isothiourea of the formula: ##STR7## wherein n is 2, 3 or 4; R 1 and R 2 , which may be the same or different, are lower alkyl; and R 3 and R 4 , which may be the same or different, together form a --(CH 2 ) x -- group where x is 2, 3 or 4, or a pharmaceutically acceptable acid salt thereof.
Claim 14
Dependent Claim
17 words
A method according to claim 8 wherein the isothiourea is 2-(2-dimethylaminoethylthio)-2-imidazoline or a pharmaceutically acceptable salt thereof.
References Cited (Backward Citations)
US2813102A
Cited
US3334112A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-05-27 | 1983-11-26 | 1984-05-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-05-27 | 1987-11-26 | 1988-05-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-05-27 | 1991-11-26 | 1992-05-27 | $7700.00 | Window Closed / Lapsed |