Selenium-75 labelled derivatives of folates
Abstract
Abstract Novel selenium-75 derivatives of folates, which are useful in competitive radio assay of folates, have the general formula: ##STR1## where a dotted bond line indicates that the bond may be single or double, and where X is H or --CH 3 , m is 0 or 1 (such that the adjacent nitrogen atom is trivalent), and either (a) R is ##STR2## and is attached through the nitrogen atom to the pteroyl residue where q is 0 or 1 p is 1 or 2 Q is C x H 2x+1 where x is from 1 to 6 and when q is 0, Z is H and when q is 1, Z is HO, or (b) R is --CO.CHY.CHY.CH(COOH)NH-- and is attached through the nitrogen atom to the pteroyl residue, where Z is HO, one group Y is --H and the other group Y is --SeC x H 2x+1 where x is from 1 to 6 and esters and salts of such acid.
Inventors
- 👤 Russell J. Bayly
- 👤 Virginia E. M. Chambers
- 👤 Reginald Monks
Bibliographic Details
Claims Analysis
Total Claims: 10References Cited (Backward Citations)
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