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US4202976A Expired / Lapsed US ⏱️ 0.0 years remaining

Selenium-75 labelled derivatives of folates

Assignee: Individual
•
Filing: 1977-11-21
•
Granted: 1980-05-13
•
Expires: 1997-11-21
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Abstract

Abstract Novel selenium-75 derivatives of folates, which are useful in competitive radio assay of folates, have the general formula: ##STR1## where a dotted bond line indicates that the bond may be single or double, and where X is H or --CH 3 , m is 0 or 1 (such that the adjacent nitrogen atom is trivalent), and either (a) R is ##STR2## and is attached through the nitrogen atom to the pteroyl residue where q is 0 or 1 p is 1 or 2 Q is C x H 2x+1 where x is from 1 to 6 and when q is 0, Z is H and when q is 1, Z is HO, or (b) R is --CO.CHY.CHY.CH(COOH)NH-- and is attached through the nitrogen atom to the pteroyl residue, where Z is HO, one group Y is --H and the other group Y is --SeC x H 2x+1 where x is from 1 to 6 and esters and salts of such acid.

Inventors

  • 👤 Russell J. Bayly
  • 👤 Virginia E. M. Chambers
  • 👤 Reginald Monks

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-11-03 16:50
CPC Classifications
C; C07; C07D; C07D475/00; C07D475/02; C07D475/04; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/82

Claims Analysis

Total Claims: 10
Claim 1
Independent Claim 153 words
A compound having the general formula (III) ##STR7## where a dotted bond line indicates that the bond may be single or double, and where X is H or --CH 3 , m is 0 or 1 (such that the adjacent nitrogen atom is trivalent), and either (a) R is ##STR8## and is attached through the nitrogen atom to the pteroyl residue where q is 0 or 1 p is 1 or 2 Q is C x H 2x+1 where x is from 1 to 6 and when q is 0, Z is H and when q is 1, Z is HO, or (b) R is --CO.CHY.CHY.CH(COOH)NH-- and is attached through the nitrogen atom to the pteroyl residue, where Z is HO, one group Y is --H and the other group Y is --Se 75 C x H 2x+1 where x is from 1 to 6 or an ester or salt of such acid.
Claim 2
Dependent Claim 153 words
A compound having the general formula (III) ##STR7## where a dotted bond line indicates that the bond may be single or double, and where X is H or --CH 3 , m is 0 or 1 (such that the adjacent nitrogen atom is trivalent), and either (a) R is ##STR8## and is attached through the nitrogen atom to the pteroyl residue where q is 0 or 1 p is 1 or 2 Q is C x H 2x+1 where x is from 1 to 6 and when q is 0, Z is H and when q is 1, Z is HO, or (b) R is --CO.CHY.CHY.CH(COOH)NH-- and is attached through the nitrogen atom to the pteroyl residue, where Z is HO, one group Y is --H and the other group Y is --Se 75 C x H 2x+1 where x is from 1 to 6 or an ester or salt of such acid.
Claim 3
Dependent Claim 1 words
N-Pteroyl-Se-methyl-L-selenocysteine-Se75.
Claim 4
Dependent Claim 1 words
N-Pteroyl-Se-methyl-L-selenocysteine-Se75.
Claim 5
Dependent Claim 1 words
N-Pteroyl-L-selenomethionine-Se75.
Claim 6
Dependent Claim 1 words
N-Pteroyl-L-selenomethionine-Se75.
Claim 7
Dependent Claim 1 words
N-Pteroyl-2-(methylseleno)-ethylamine-Se75.
Claim 8
Dependent Claim 1 words
N-Pteroyl-2-(methylseleno)-ethylamine-Se75.
Claim 9
Dependent Claim 17 words
A compound according to claim 1 wherein R is as defined in (a) and x is 1.
Claim 10
Dependent Claim 17 words
A compound according to claim 1 wherein R is as defined in (b) and x is 1.

References Cited (Backward Citations)

US3993741A Cited
US3988431A Cited
US4038033A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1983-05-13 1983-11-12 1984-05-13 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1987-05-13 1987-11-12 1988-05-13 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1991-05-13 1991-11-12 1992-05-13 $7700.00 Window Closed / Lapsed

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