US4200755A
Expired / Lapsed
US
⏱️ 0.0 years remaining
2-Hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid derivatives
Assignee: Richardson Vicks Inc
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Filing: 1979-05-04
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Granted: 1980-04-29
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Expires: 1999-05-04
Abstract
Abstract Derivatives of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl ]benzoic acid are prepared which are useful for their blocking action on alpha and beta -adrenergic receptors. In addition, these compounds are useful for their spasmolytic and anti-hypertensive activity.
Inventors
- 👤 J. Martin Grisar
- 👤 George P. Claxton
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-03 10:40
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/04; A; A61; A61P; A61P9/00; A61P9/06; A61P9/08; A61P9/10; A61P9/12
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
67 words
A derivative of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid having the formula ##STR3## wherein X is selected from the group consisting of hydroxy, methoxy, ethoxy, amino, dimethylamino and alkylamino in which the alkyl group has from 1 to 12 carbon atoms; R 1 is hydrogen, methyl or ethyl; R 2 and R 3 are hydrogen or when taken together form a double bond; and the pharmaceutically acceptable acid addition salts thereof.
Claim 2
Dependent Claim
67 words
A derivative of 2-hydroxy-5-[1-hydroxy-2-[4-(2-oxo-1-benzimidazolinyl)piperidino]ethyl]benzoic acid having the formula ##STR3## wherein X is selected from the group consisting of hydroxy, methoxy, ethoxy, amino, dimethylamino and alkylamino in which the alkyl group has from 1 to 12 carbon atoms; R 1 is hydrogen, methyl or ethyl; R 2 and R 3 are hydrogen or when taken together form a double bond; and the pharmaceutically acceptable acid addition salts thereof.
Claim 3
Dependent Claim
36 words
A compound according to claim 1 wherein X is amino, dimethylamino or alkylamino in which the alkyl group has from 1 to 12 carbon atoms; and R 1 , R 2 and R 3 are hydrogen.
Claim 4
Dependent Claim
23 words
A compound according to claim 1 wherein X is methoxy or ethoxy; and R 1 , R 2 and R 3 are hydrogen.
Claim 5
Dependent Claim
16 words
A compound of claim 1 which is methyl 2-hydroxy-5-[2-[4-(2-oxo-1-benzimidazolinyl)-1-piperidinyl]-1-hydroxyethyl]benzoate and its pharmaceutically acceptable acid addition salts.
Claim 6
Dependent Claim
15 words
A compound of claim 1 which is 2-hydroxy-5-[2-[4-(2-oxo-1-benzimidazolinyl)-1-piperidinyl]-1-hydroxyethyl]benzamide and its pharmaceutically acceptable acid addition salts.
Claim 7
Dependent Claim
15 words
A compound of claim 1 which is 2-hydroxy-5-[2-[4-(2-oxo-1-benzimidazolinyl)-1-piperidinyl]-1-hydroxyethyl]-N-ethylbenzamide and its pharmaceutically acceptable acid addition salts.
References Cited (Backward Citations)
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US3318900A
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US4080328A
Cited
US3818017A
Cited
US3894030A
Cited
US3929801A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-29 | 1983-10-29 | 1984-04-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-29 | 1987-10-29 | 1988-04-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-29 | 1991-10-29 | 1992-04-29 | $7700.00 | Window Closed / Lapsed |