Triazinones for veterinary use

Claim 1

A veterinary composition suitable for treating diarrhea in animals comprising an effective amount of a compound of the formula: ##STR3## wherein R 1 is phenyl, benzyl or phenethyl; or phenyl, benzyl or phenethyl in which one or more of the phenyl hydrogens are substituted by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; pyridyl or pyridyl having one or more hydrogens replaced by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; R 2 is hydrogen or lower alkyl, and R 3 and R 4 are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkanoyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halo-lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, phenoxy lower alkyl, di-lower alkyl-amino lower alkyl or R 3 and R 4 together with the nitrogen to which they are attached form a 5 or 6 membered nitrogen heterocycle containing 0 to 1 additional hetero atoms which may be nitrogen, oxygen, or sulfur or a non-toxic salt thereof in combination with an acceptable food carrier for administering the compound in the animal diet.

Claim 12

A method for remedial or preventive treatment of animal scours which comprises administering by oral route an effective amount of a composition comprising a compound of the formula: ##STR5## wherein R 1 is phenyl, benzyl or phenethyl; or phenyl, benzyl or phenethyl in which one or more of the phenyl hydrogens are substituted by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; pyridyl or pyridyl having one or more hydrogens replaced by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; R 2 is hydrogen or lower alkyl, and R 3 and R 4 are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkanoyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halo lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, phenoxy lower alkyl, di-lower alkyl-amino lower alkyl or R 3 and R 4 together with the nitrogen to which they are attached form a 5 or 6 membered nitrogen heterocycle containing 0 to 1 additional hetero atoms which may be nitrogen, oxygen or sulfur; and the non-toxic salts thereof; in combination with an acceptable carrier.

Claim 13

A method for remedial or preventive treatment of animal scours which comprises administering by oral route an effective amount of a composition comprising a compound of the formula: ##STR5## wherein R 1 is phenyl, benzyl or phenethyl; or phenyl, benzyl or phenethyl in which one or more of the phenyl hydrogens are substituted by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; pyridyl or pyridyl having one or more hydrogens replaced by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; R 2 is hydrogen or lower alkyl, and R 3 and R 4 are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkanoyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halo lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, phenoxy lower alkyl, di-lower alkyl-amino lower alkyl or R 3 and R 4 together with the nitrogen to which they are attached form a 5 or 6 membered nitrogen heterocycle containing 0 to 1 additional hetero atoms which may be nitrogen, oxygen or sulfur; and the non-toxic salts thereof; in combination with an acceptable carrier.

Claim 19

A method for remedial or preventive treatment of scours in food producing animals which comprises adminstering by oral route an effective amount of 1-(2'6'-dimethylphenyl-4-methylamino-1,2-dihydro-1,3,5-triazine-2-one; or an acceptable non-toxic salt thereof incorporation with a suitable carrier.

Claim 20

A method for remedial or preventive treatment of scours in food producing animals which comprises adminstering by oral route an effective amount of 1-(2'6'-dimethylphenyl-4-methylamino-1,2-dihydro-1,3,5-triazine-2-one; or an acceptable non-toxic salt thereof incorporation with a suitable carrier.

Claim 21

A method for remedial or preventive treatment of scours in food producing animals which comprises administering by oral route an effective amount of 1-(2'6'-diethylphenyl)-4-methylamino-1,2-dihydro-1,3,5-triazin-2-one; or an acceptable non-toxic salt thereof incorporated with a suitable carrier.

Claim 22

A method for remedial or preventive treatment of scours in food producing animals which comprises administering by oral route an effective amount of 1-(2'6'-diethylphenyl)-4-methylamino-1,2-dihydro-1,3,5-triazin-2-one; or an acceptable non-toxic salt thereof incorporated with a suitable carrier.