US4198409A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Triazinones for veterinary use
Assignee: William H Rorer Inc
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Filing: 1978-11-13
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Granted: 1980-04-15
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Expires: 1998-11-13
Abstract
Abstract New compositions containing as the principle active ingredient a 1,4-disubstituted-1,2-dihydro-1,3,5-triazin-2-one are used for remedial or prophylactic treatment of diarrhea and organic gastrointestinal disorders accompanied by diarrheal symptoms.
Inventors
- 👤 John Yelnosky
- 👤 George H. Douglas
- 👤 Ghulam N. Mir
- 👤 Dahyabhai M. Patel
- 👤 Chong M. Won
- 👤 Ronald L. Alioto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-08 13:24
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/535; A61K31/53; A61K31/54; C; C07; C07D; C07D251/00; C07D251/02; C07D251/12; C07D251/26; C07D251/40; C07D251/42
Claims Analysis
Total Claims: 22
Claim 1
Independent Claim
198 words
A veterinary composition suitable for treating diarrhea in animals comprising an effective amount of a compound of the formula: ##STR3## wherein R 1 is phenyl, benzyl or phenethyl; or phenyl, benzyl or phenethyl in which one or more of the phenyl hydrogens are substituted by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; pyridyl or pyridyl having one or more hydrogens replaced by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; R 2 is hydrogen or lower alkyl, and R 3 and R 4 are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkanoyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halo-lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, phenoxy lower alkyl, di-lower alkyl-amino lower alkyl or R 3 and R 4 together with the nitrogen to which they are attached form a 5 or 6 membered nitrogen heterocycle containing 0 to 1 additional hetero atoms which may be nitrogen, oxygen, or sulfur or a non-toxic salt thereof in combination with an acceptable food carrier for administering the compound in the animal diet.
Claim 2
Dependent Claim
198 words
A veterinary composition suitable for treating diarrhea in animals comprising an effective amount of a compound of the formula: ##STR3## wherein R 1 is phenyl, benzyl or phenethyl; or phenyl, benzyl or phenethyl in which one or more of the phenyl hydrogens are substituted by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; pyridyl or pyridyl having one or more hydrogens replaced by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; R 2 is hydrogen or lower alkyl, and R 3 and R 4 are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkanoyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halo-lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, phenoxy lower alkyl, di-lower alkyl-amino lower alkyl or R 3 and R 4 together with the nitrogen to which they are attached form a 5 or 6 membered nitrogen heterocycle containing 0 to 1 additional hetero atoms which may be nitrogen, oxygen, or sulfur or a non-toxic salt thereof in combination with an acceptable food carrier for administering the compound in the animal diet.
Claim 3
Dependent Claim
69 words
A composition according to claim 1 wherein the active ingredient is a compound of the formula: ##STR4## wherein R 3 and R 4 are independently selected from the group consisting of hydrogen, lower alkyl, hydroxyl, or lower alkoxy and R 5 and R 6 are each independently selected from the group consisting of hydrogen, halo, lower alkyl, lower alkoxy or halo lower alkyl and their pharmaceutically acceptable non-toxic salts.
Claim 4
Dependent Claim
11 words
A composition according to claim 2 wherein R 3 is hydrogen.
Claim 5
Dependent Claim
15 words
A composition according to claim 3 wherein R 4 is lower alkyl or lower alkoxy.
Claim 6
Dependent Claim
24 words
A composition according to claim 4 wherein each of R 5 and R 6 is lower alkyl which may be the same or different.
Claim 7
Dependent Claim
12 words
A composition according to claim 5 wherein R 4 is lower alkyl.
Claim 8
Dependent Claim
27 words
A veterinary composition for the treatment of diarrhea in animals comprising an effective amount of 1-(2'6'-dimethylphenyl)-4-methylamino-1,2-dihydro-1,3,5-triazin-2-one; or a non-toxic salt thereof together with an edible food carrier.
Claim 9
Dependent Claim
27 words
A veterinary composition for the treatment of diarrhea in animals comprising an effective amount of 1-(2'6'-dimethylphenyl)-4-methylamino-1,2-dihydro-1,3,5-triazin-2-one; or a non-toxic salt thereof together with an edible food carrier.
Claim 10
Dependent Claim
27 words
A veterinary composition for the treatment of diarrhea in animals comprising an effective amount of 1-(2'6'-diethylphenyl)-4-methylamino-1,2-dihydro-1,3,5-triazin-2-one; or a non-toxic salt thereof together with an edible food carrier.
Claim 11
Dependent Claim
27 words
A veterinary composition for the treatment of diarrhea in animals comprising an effective amount of 1-(2'6'-diethylphenyl)-4-methylamino-1,2-dihydro-1,3,5-triazin-2-one; or a non-toxic salt thereof together with an edible food carrier.
Claim 12
Independent Claim
199 words
A method for remedial or preventive treatment of animal scours which comprises administering by oral route an effective amount of a composition comprising a compound of the formula: ##STR5## wherein R 1 is phenyl, benzyl or phenethyl; or phenyl, benzyl or phenethyl in which one or more of the phenyl hydrogens are substituted by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; pyridyl or pyridyl having one or more hydrogens replaced by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; R 2 is hydrogen or lower alkyl, and R 3 and R 4 are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkanoyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halo lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, phenoxy lower alkyl, di-lower alkyl-amino lower alkyl or R 3 and R 4 together with the nitrogen to which they are attached form a 5 or 6 membered nitrogen heterocycle containing 0 to 1 additional hetero atoms which may be nitrogen, oxygen or sulfur; and the non-toxic salts thereof; in combination with an acceptable carrier.
Claim 13
Independent Claim
199 words
A method for remedial or preventive treatment of animal scours which comprises administering by oral route an effective amount of a composition comprising a compound of the formula: ##STR5## wherein R 1 is phenyl, benzyl or phenethyl; or phenyl, benzyl or phenethyl in which one or more of the phenyl hydrogens are substituted by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; pyridyl or pyridyl having one or more hydrogens replaced by lower alkyl, lower alkoxy, halo, halo-lower alkyl, amino, nitro, acyloxy, acylamino, hydroxy, cyano, carboxyl, or lower alkyl sulfonyl; R 2 is hydrogen or lower alkyl, and R 3 and R 4 are each independently selected from the group consisting of hydrogen, hydroxyl, lower alkanoyl, lower alkyl, lower alkenyl, lower alkynyl, lower alkoxy, halo lower alkyl, hydroxy lower alkyl, lower alkoxy lower alkyl, phenoxy lower alkyl, di-lower alkyl-amino lower alkyl or R 3 and R 4 together with the nitrogen to which they are attached form a 5 or 6 membered nitrogen heterocycle containing 0 to 1 additional hetero atoms which may be nitrogen, oxygen or sulfur; and the non-toxic salts thereof; in combination with an acceptable carrier.
Claim 14
Dependent Claim
69 words
A method according to claim 9 wherein the active ingredient is a compound of the formula: ##STR6## wherein R 3 and R 4 are independently selected from the group consisting of hydrogen, lower alkyl, hydroxyl, or lower alkoxy and R 5 and R 6 are each independently selected from the group consisting of hydrogen, halo, lower alkyl, lower alkoxy or halo lower alkyl and the acceptable non-toxic salts thereof.
Claim 15
Dependent Claim
11 words
A method according to claim 10 wherein R 3 is hydrogen.
Claim 16
Dependent Claim
15 words
A method according to claim 11 wherein R 4 is lower alkyl or lower alkoxy.
Claim 17
Dependent Claim
24 words
A method according to claim 12 wherein each of R 5 and R 6 is lower alkyl which may be the same or different.
Claim 18
Dependent Claim
12 words
A method according to claim 13 wherein R 4 is lower alkyl.
Claim 19
Independent Claim
35 words
A method for remedial or preventive treatment of scours in food producing animals which comprises adminstering by oral route an effective amount of 1-(2'6'-dimethylphenyl-4-methylamino-1,2-dihydro-1,3,5-triazine-2-one; or an acceptable non-toxic salt thereof incorporation with a suitable carrier.
Claim 20
Independent Claim
35 words
A method for remedial or preventive treatment of scours in food producing animals which comprises adminstering by oral route an effective amount of 1-(2'6'-dimethylphenyl-4-methylamino-1,2-dihydro-1,3,5-triazine-2-one; or an acceptable non-toxic salt thereof incorporation with a suitable carrier.
Claim 21
Independent Claim
35 words
A method for remedial or preventive treatment of scours in food producing animals which comprises administering by oral route an effective amount of 1-(2'6'-diethylphenyl)-4-methylamino-1,2-dihydro-1,3,5-triazin-2-one; or an acceptable non-toxic salt thereof incorporated with a suitable carrier.
Claim 22
Independent Claim
35 words
A method for remedial or preventive treatment of scours in food producing animals which comprises administering by oral route an effective amount of 1-(2'6'-diethylphenyl)-4-methylamino-1,2-dihydro-1,3,5-triazin-2-one; or an acceptable non-toxic salt thereof incorporated with a suitable carrier.
References Cited (Backward Citations)
US4068081A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-04-15 | 1983-10-15 | 1984-04-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-04-15 | 1987-10-15 | 1988-04-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-04-15 | 1991-10-15 | 1992-04-15 | $7700.00 | Window Closed / Lapsed |