Salts of N-glycosyl derivatives of polyene macrolides, especially N-methylglucamine salts as well as the method of their preparation
Abstract
Abstract The new compounds, N-methylglucamine salts of N-glycosyl derivatives of polyene macrolides particularly N-methylglucamine salts of N-glycosyl derivatives of amphotericin B, polifungin and nystatin are described herein. These compounds exhibit high pharamacological activity in some topical and sistemic fungal infections. The product is prepared by reaction of an amino group containing polyene macrolide with an aldose or ketose mono- or oligosaccharide, in an organic solvent medium or in the mixture of solvents characterized in that the formed N-glycosyl derivatives is precipitated from the reaction medium by water or with an aqueous solution of inorganic salt, preferably ammonium sulphate, and after crystallization from a higher alkanol of C3-6 atoms, preferably n-butanol transformed into a salt, preferably an N-methylglucamine salt and then crystallized from higher alkanol, preferably n-butanol.
Inventors
- 👤 Leonard Falkowski
- 👤 Zuzanna Kowszyk-Gindifer
- 👤 Zofia Plociennik
- 👤 Jan Zielinski
- 👤 Halina Dahlig
- 👤 Jerzy Golik
- 👤 Ewa Jakobs
- 👤 Pawel Kolodziejczyk
- 👤 Elzbieta Bylec
- 👤 Danuta Roslik-Kaminska
- 👤 Wladyslawa Wagner
- 👤 Jan Pawlak
- 👤 Edward Borowski
Bibliographic Details
Claims Analysis
Total Claims: 6References Cited (Backward Citations)
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