Patent US4195128A successfully refreshed from Google Patents.
US4195128A
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Polymeric carrier bound ligands
Assignee: Bayer AG
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Filing: 1978-10-02
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Granted: 1980-03-25
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Expires: 1998-10-02
Abstract
Abstract A process for bonding a ligand to a carrier through the use of a pyrimidine derivative of the formula: ##STR1## in which R 1 , R 2 , R 3 and R 4 are each independently hydrogen, hydroxyl, halogen, lower alkyl, lower alkoxy, loweralkylthio, loweracylamino, nitro, cyano, carboxamido, loweralkylsulphonyl, loweralkoxycarbonyl, phenyl, trifluoromethyl or chloromethyl, the ligand or the carrier containing at least one functional group that reacts with the pyramidine derivative.
Inventors
- 👤 Dietrich Hildebrand
- 👤 Thomas Gribnau
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-04 06:08
CPC Classifications
C; C08; C08B; C08B11/00; C08B37/00; C08B37/0006; C08B37/0036; C08B37/0039; C08F; C08F8/00; C08F8/30; C12; C12N; C12N11/00; C12N11/02; C12N11/08; C12N11/082; C12N11/087; C12N11/089; C12N11/091; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/813; Y10S530/814; Y10S530/815; Y10S530/816
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
75 words
A carrier bound ligand of the formula: T--X--P--X--L wherein T represents the residue of a polymeric carrier; X is independently a divalent oxygen or sulfur atom, --NH--, --NHR 5 --, --CONH-- or --CONR 5 --, wherein R 5 is lower alkyl; L is the residue of a ligand; and P is ##STR13## wherein each R 6 is hydrogen, hydroxyl, lower alkyl, lower alkoxy, loweralkylthio, loweracylamino, nitro, cyano, carboxamide, loweralkylsulphonyl, loweralkoxycarbonyl, phenyl, trifluoromethyl, chloromethyl or T--X--.
Claim 2
Dependent Claim
75 words
A carrier bound ligand of the formula: T--X--P--X--L wherein T represents the residue of a polymeric carrier; X is independently a divalent oxygen or sulfur atom, --NH--, --NHR 5 --, --CONH-- or --CONR 5 --, wherein R 5 is lower alkyl; L is the residue of a ligand; and P is ##STR13## wherein each R 6 is hydrogen, hydroxyl, lower alkyl, lower alkoxy, loweralkylthio, loweracylamino, nitro, cyano, carboxamide, loweralkylsulphonyl, loweralkoxycarbonyl, phenyl, trifluoromethyl, chloromethyl or T--X--.
Claim 3
Dependent Claim
19 words
The product according to claim 1, wherein the polymeric carrier is agarose, crosslinked dextran, cellulose, polyacrylamide or aminomethylated polystyrene.
Claim 4
Dependent Claim
12 words
The product according to claim 1, wherein the polymeric carrier is agarose.
Claim 5
Dependent Claim
17 words
The product according to claim 1, wherein the ligand is p-aminobenzamidine, an azo dyestuff, insulin or penicillinase.
Claim 6
Dependent Claim
11 words
The product according to claim 3, wherein the ligand is insulin.
Claim 7
Dependent Claim
11 words
The product according to claim 3, wherein the ligand is penicillinase.
References Cited (Backward Citations)
US4007089A
Cited
US4069105A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-25 | 1983-09-24 | 1984-03-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-25 | 1987-09-24 | 1988-03-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-25 | 1991-09-24 | 1992-03-25 | $7700.00 | Window Closed / Lapsed |