Patent US5972178A successfully refreshed from Google Patents.
Patent US4192885A successfully refreshed from Google Patents.
US4192885A
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Analgesic N-{2-[N'-(2-furylmethyl and 2-thienyl-methyl)-N'-alkylamino]cycloaliphatic}cyanobenzamides
Assignee: Pharmacia and Upjohn Co
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Filing: 1979-03-08
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Granted: 1980-03-11
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Expires: 1999-03-08
Abstract
Abstract Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula ##STR1## e.g., N-methyl-N-[2-(N-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.
Inventors
- 👤 Jacob Szmuszkovicz
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-11-09 03:59
CPC Classifications
C; C07; C07D; C07D295/00; C07D295/04; C07D295/12; C07D295/135
Claims Analysis
Total Claims: 7
Claim 1
Independent Claim
107 words
A compound of the formula ##STR63## wherein the wavy line (˜) at the 1-position of the cycloaliphatic ring denotes trans-stereoconfiguration of the 1-position substituent with respect to the substituent in position 2 of the same cycloaliphatic ring; n is 1 to 8; R is hydrogen or C 1 to C 3 -alkyl; R 1 is C 1 to C 3 -alkyl; R 2 is a group of the formula ##STR64## wherein T is --O-- or --S--; Q is the radical ##STR65## wherein one of X, Y and Z is cyano and the remaining members of X, Y and Z are hydrogen, and the pharmaceutically acceptable salts thereof.
Claim 2
Dependent Claim
107 words
A compound of the formula ##STR63## wherein the wavy line (˜) at the 1-position of the cycloaliphatic ring denotes trans-stereoconfiguration of the 1-position substituent with respect to the substituent in position 2 of the same cycloaliphatic ring; n is 1 to 8; R is hydrogen or C 1 to C 3 -alkyl; R 1 is C 1 to C 3 -alkyl; R 2 is a group of the formula ##STR64## wherein T is --O-- or --S--; Q is the radical ##STR65## wherein one of X, Y and Z is cyano and the remaining members of X, Y and Z are hydrogen, and the pharmaceutically acceptable salts thereof.
Claim 3
Dependent Claim
17 words
A compound according to claim 1 wherein the compound is trans-4-cyano-N-{2-[N'-(2-furylmethyl)-N'-methylamino]cyclohexyl}-N-methylbenzamide, or a pharmaceutically acceptable salt thereof.
Claim 4
Dependent Claim
17 words
A compound according to claim 1 wherein the compound is trans-4-cyano-N-{2[N'-(2-thienylmethyl)-N'-methylamino]cyclohexyl}-N-methylbenzamide or a pharmaceutically acceptable salt thereof.
Claim 5
Dependent Claim
44 words
A composition useful in pharmaceutical dosage unit form in an amount ranging from about 0.5 to about 350 mg. per dosage unit for alleviating pain in a warm blooded animals which comprises a compound of claim 1 in combination with a pharmaceutically acceptable carrier.
Claim 6
Dependent Claim
33 words
A method for alleviating pain in a warm blooded animal which comprises administering to the warm blooded animal suffering pain a compound of claim 1 in an amount effective to relieve the pain.
Claim 7
Dependent Claim
29 words
A method according to claim 5 wherein the compound of claim 1 is administered in an amount between about 0.5 and 350 mg. per dose in a pharmaceutical carrier.
References Cited (Backward Citations)
US3510492A
Cited
US3647804A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-11 | 1983-09-10 | 1984-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-11 | 1987-09-10 | 1988-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-11 | 1991-09-10 | 1992-03-11 | $7700.00 | Window Closed / Lapsed |