Patent US3970945A successfully refreshed from Google Patents.
Patent US4192879A successfully refreshed from Google Patents.
US4192879A
Expired / Lapsed
US
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Imidazolyl alkylamino nitroethylene compounds
Assignee: Smith Kline & French Laboratories Ltd
•
Filing: 1978-03-31
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Granted: 1980-03-11
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Expires: 1998-03-31
Abstract
Abstract The compounds are novel N-substituted-N'-heterocyclic alkylthioureas, guanidines and 1-nitro-2,2-diaminoethylene compounds which are histamine H2-antagonists.
Inventors
- 👤 Graham J. Durant
- 👤 Charon R. Ganellin
- 👤 Geoffrey R. Owen
- 👤 Rodney C. Young
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-27 08:37
CPC Classifications
C; C07; C07D; C07D233/00; C07D233/54; C07D233/64; C07D277/00; C07D277/02; C07D277/20; C07D277/22; C07D277/26
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
85 words
A compound of the formula: ##STR19## wherein X is CHNO 2 ; Y is amino, lower alkylamino, di(lower alkyl)amino, lower alkoxy, phenylethyl, imidazolylethyl, allyl, 2,2,2-trifluoroethyl, or (CH 2 ) n R; Z is sulphur or methylene; Het is an imidazole ring which is attached at a ring carbon and which ring is optionally substituted by lower alkyl or halogen; n is an integer from 1 to 12; and R is hydroxy, lower alkoxy, amino or lower alkylamino; or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Dependent Claim
85 words
A compound of the formula: ##STR19## wherein X is CHNO 2 ; Y is amino, lower alkylamino, di(lower alkyl)amino, lower alkoxy, phenylethyl, imidazolylethyl, allyl, 2,2,2-trifluoroethyl, or (CH 2 ) n R; Z is sulphur or methylene; Het is an imidazole ring which is attached at a ring carbon and which ring is optionally substituted by lower alkyl or halogen; n is an integer from 1 to 12; and R is hydroxy, lower alkoxy, amino or lower alkylamino; or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
17 words
A compound according to claim 1 wherein Het is imidazole optionally substituted by methyl, chloro or bromo.
Claim 4
Dependent Claim
10 words
A compound according to claim 2 wherein Het is 4-methyl-5-imidazolyl.
Claim 5
Dependent Claim
24 words
A compound according to claim 1 wherein Y is amino, 2,2,2-trifluoroethyl, (CH 2 ) n OH or (CH 2 ) n NH 2 .
Claim 6
Dependent Claim
37 words
A compound according to claim 1 wherein Y is amino, lower alkoxy, phenylethyl, imidazolylethyl, 2,2,2-trifluoroethyl or (CH 2 ) n R; n is an integer from 1 to 11 and R is hydroxy, lower alkoxy or amino.
Claim 7
Dependent Claim
22 words
A compound according to claim 5 wherein n is an integer from 1 to 7 and R is hydroxy or lower alkoxy.
Claim 8
Dependent Claim
9 words
A compound of claim 1, said compound being 1-nitro-2-hydrazino-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]ethylene.
Claim 9
Dependent Claim
9 words
A compound of claim 1, said compound being 1-nitro-2-(2,2,2-trifluoroethylamino)-2-[2-((4-methyl-5-imidazolyl)methylthio)ethylamino]ethylene.
Claim 10
Dependent Claim
30 words
A pharmaceutical composition to block histamine H 2 -receptors comprising in an effective amount to block said receptors a compound according to claim 1 and a pharmaceutical diluent or carrier.
Claim 11
Dependent Claim
30 words
A method of blocking histamine H 2 -receptors which comprises administering to an animal in need thereof in an effective amount to block said receptors a compound of claim 1.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-03-11 | 1983-09-10 | 1984-03-11 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-03-11 | 1987-09-10 | 1988-03-11 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-03-11 | 1991-09-10 | 1992-03-11 | $7700.00 | Window Closed / Lapsed |