1-Aryloxy-2-hydroxy-3-aminopropanes

Abstract

Abstract Compounds of formula I ##STR1## wherein R 1 and R 1' are identical or different and represent hydrogen, an alkyl radical or alkoxy radical having 1-4 carbon atoms, the allyl group, a halogen atom or the nitro group, R 2 represents an acrylic acid radical or an acrylic acid nitrile radical of the formulae ##STR2## wherein R 5 represents hydrogen, an alkyl radical having 1-5 carbon atoms, an aryl radical or aryl-lower alkyl radical either unsubstituted or substituted by lower alkyl or alkoxy, R 6 represents hydrogen or an alkyl radical having 1-8 carbon atoms, R 7 represents hydrogen, a lower alkyl radical or an aryl-lower alkyl radical, R 3 and R 4 represent together with the nitrogen atom a heterocyclic ring with 5-7 members being optionally substituted by C 1 -C 4 alkyl, in which ring one carbon atom may be replaced by one oxygen atom, sulfur atom or one further nitrogen atom, the latter may be substituted, or wherein R 3 represents hydrogen and R 4 represents a phenyl-alkylene or phenyl-alkylidene radical of the formula ##STR3## in which Alk is alkyl having 1 to 3 carbon atoms, and n is a figure from 1-3, and R 8 and R 9 are identical or different and represent hydrogen, an alkoxy radical having 1-3 carbon atoms or the benzoyl radical or R 8 and R 9 represent together the bismethylene dioxy radical, as well as the physiologically compatible acid addition salts and a process for preparing these compounds.

Inventors

• 👤 Werner Fritsch
• 👤 Ulrich Stache
• 👤 Ernst Lindner

Bibliographic Details